TBL1X and NCOR1

Number of citations of the paper that reports this interaction (PMID 12628926)
122

Data Source:
HPRD (in vitro)

		TBL1X	NCOR1
Gene Name		transducin (beta)-like 1X-linked	nuclear receptor corepressor 1
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Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Spindle Microtubule Membrane Sin3 Complex Transcriptional Repressor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Deacetylase Regulator Activity Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Proteolysis Notch Signaling Pathway Sensory Perception Of Sound Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Chromatin Organization Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Circadian Rhythm Gene Expression Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Chromatin Modification Thalamus Development Positive Regulation Of Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Multicellular Organism Growth Cholesterol Homeostasis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of JNK Cascade Spindle Assembly Definitive Erythrocyte Differentiation Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Fatty Acid Transport
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression	Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity RORA activates circadian gene expression Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Chromatin organization HDACs deacetylate histones Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer REV-ERBA represses gene expression Signaling by ERBB4 Loss of Function of TGFBR1 in Cancer Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Nuclear signaling by ERBB4 Chromatin modifying enzymes Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		25 interactors: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 GPS2 HDAC3 HIST1H4A HIST2H2AA3 HIST2H2BE HIST2H3C HIST2H4A HP HR KHDRBS1 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1	85 interactors: ACTN2 AR ATXN1 ATXN1L ATXN3 BAZ1A BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ESR1 ESR2 ETS1 ETS2 GPS2 GTF2B HDAC3 HDAC5 HDAC9 HESX1 HEY2 HIST1H3A HIST1H4A HTT MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 PDCD2 PHB PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRB TXNRD2 VDR ZBTB16 ZBTB33 ZMYND11
Entrez ID		6907	9611
HPRD ID		02183	02911
Ensembl ID		ENSG00000101849	ENSG00000141027
Uniprot IDs		O60907	O75376 Q6PGR4
PDB IDs		2XTC 2XTD 2XTE	2EQR 3H52 3KMZ 3N00 4II6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Type I Pneumocyte Differentiation Nucleobase-containing Compound Metabolic Process Lung Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Notch Signaling Pathway DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Telomere Maintenance Gene Expression Regulation Of Chromosome Organization Chromatin Modification Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Female Courtship Behavior DNA-templated Transcription, Initiation Organelle Organization Negative Regulation Of JNK Cascade Histone H4-K20 Demethylation Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Stress-activated MAPK Cascade Chromatin Silencing Transcription, DNA-templated Mitotic Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Macromolecule Biosynthetic Process Lung Epithelial Cell Differentiation	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Cellular Metabolic Process Response To Steroid Hormone Cellular Response To Organic Substance Cellular Response To Lipid Regulation Of Cell Differentiation Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Cellular Process Response To Organic Substance
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1	acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 mfap4 morphants morpholino mpx myelopoiesis ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1	acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 mfap4 morphants morpholino mpx myelopoiesis ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Intersection) ?