TBL1X and TBL1XR1

Number of citations of the paper that reports this interaction (PubMedID 15601853)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		TBL1X	TBL1XR1
Description		transducin beta like 1 X-linked	TBL1X/Y related 1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Histone Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Response To Dietary Excess Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Lipid Catabolic Process Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Adipose Tissue Development Fat Pad Development Regulation Of Triglyceride Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Refractive error ( 32231278)	Asthma ( 34103634 32296059 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Central corneal thickness ( 31798171 32528159 29760442) Chin dimples ( 27182965) Chronotype ( 30696823) Corneal structure ( 23291589) Early chronic obstructive pulmonary disease in never smokers ( 33235445) Esophageal cancer ( 21642993) Inflammatory skin disease ( 25574825) Mastocytosis (KIT D816V positive) ( 33421400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)
Interacting Genes		31 interacting genes: ARL2 ARL3 CDC34 CORO2A CTNNB1 DDB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I	15 interacting genes: ARL2 CEBPA CORO2A DDB1 FOXK2 GPS2 H2BC21 H4C14 H4C6 HDAC3 MECP2 NCOR1 OGT TBL1X UBE2I
Entrez ID		6907	79718
HPRD ID		02183	15476
Ensembl ID		ENSG00000101849	ENSG00000177565
Uniprot IDs		O60907	C9JLJ1 Q9BZK7
PDB IDs		2XTC 2XTD 2XTE	4LG9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Transcription Corepressor Activity Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Structural Constituent Of Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Nucleosome Regulation Of Primary Metabolic Process Female Courtship Behavior Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Chromatin Lung Epithelial Cell Differentiation Lung Cell Differentiation Chromosome, Telomeric Region Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Chromatin Binding Chromosome Regulation Of RNA Metabolic Process Thyroid Hormone Binding Negative Regulation Of JNK Cascade Shelterin Complex Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleosome Assembly Nuclear Body Negative Regulation Of Intracellular Signal Transduction Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Localization In Organelle Modification-dependent Protein Catabolic Process	Transcription Repressor Complex Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Developmental Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of JNK Cascade Cellular Component Assembly Regulation Of Small Molecule Metabolic Process Histone Deacetylase Complex Nucleus Regulation Of Glycolytic Process Chromatin Remodeling Negative Regulation Of Cell Differentiation DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II Rhythmic Process Transcription Cis-regulatory Region Binding Spindle Assembly Negative Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Glucose Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Nucleosome Assembly Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Metabolic Process Nucleosome Histone Deacetylase Binding Protein Heterodimerization Activity Nucleosome Organization Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Mitotic Spindle Regulation Of Nucleobase-containing Compound Metabolic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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