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TBL1X and KHDRBS1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
TBL1X
KHDRBS1
Gene Name
transducin (beta)-like 1X-linked
KH domain containing, RNA binding, signal transduction associated 1
Image
Gene Ontology Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Spindle Microtubule
Transcriptional Repressor Complex
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Grb2-Sos Complex
Molecular Function
Transcription Corepressor Activity
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Protein Domain Specific Binding
Histone Binding
Transcription Regulatory Region DNA Binding
DNA Binding
RNA Binding
SH3/SH2 Adaptor Activity
Protein Binding
Poly(A) Binding
Poly(U) RNA Binding
SH3 Domain Binding
Protein Complex Binding
Identical Protein Binding
Poly(A) RNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Organization
Transcription, DNA-templated
Proteolysis
Notch Signaling Pathway
Sensory Perception Of Sound
Histone Deacetylation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Canonical Wnt Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Transcription, DNA-templated
MRNA Processing
Cell Cycle Arrest
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Proliferation
Positive Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Translational Initiation
Regulation Of RNA Export From Nucleus
Positive Regulation Of RNA Export From Nucleus
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
PPARA activates gene expression
Organelle biogenesis and maintenance
Metabolism of lipids and lipoproteins
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RORA activates circadian gene expression
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
Signaling by NOTCH1
Transcriptional regulation of white adipocyte differentiation
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Orphan transporters
FBXW7 Mutants and NOTCH1 in Cancer
Fatty acid, triacylglycerol, and ketone body metabolism
Chromatin organization
HDACs deacetylate histones
Signaling by NOTCH
REV-ERBA represses gene expression
Mitochondrial biogenesis
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of gene expression by SREBF (SREBP)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
25 interactors:
CDC34
CORO2A
CTNNB1
DLX3
DNAJB4
GPS2
HDAC3
HIST1H4A
HIST2H2AA3
HIST2H2BE
HIST2H3C
HIST2H4A
HP
HR
KHDRBS1
NCOR1
NCOR2
SKP1
TAB2
TBL1XR1
TERF1
THRA
THRB
TINF2
UBE2D1
109 interactors:
ABI2
ACTB
AGO1
AHI1
AMPH
APBB1
ARHGEF4
ARHGEF9
AZIN1
BAIAP2L1
BTK
BZRAP1
CBL
CD2AP
CDK1
CIRBP
CREB3L3
CREBBP
CRK
CRKL
CSK
DDX5
DHX9
DLG1
DLG2
DLG3
DLG4
DNMBP
DOCK2
DOCK3
EFEMP1
EMG1
FGR
FNBP4
FRK
FYN
GAS7
GPHN
GRAP
GRAP2
GRB2
HCK
HNRNPK
INSR
ITK
ITSN1
ITSN2
JAK3
KHDRBS3
LCK
LYN
MAPK1
MIA2
MPP6
MYO1C
MYO7A
NCF1
NCK1
NCK2
NCKIPSD
NPHP1
OSTF1
PACSIN1
PIK3R1
PIK3R3
PLCG1
PLCG2
POT1
PPP1R13B
PRMT1
PSTPIP1
PTBP2
PTK6
PTPN6
RALY
RAPSN
RASA1
RBFOX2
RBM7
RBMX
RUSC2
SASH1
SCG5
SH3PXD2A
SH3YL1
SKAP2
SMAD2
SMARCA2
SNX30
SNX9
SORBS1
SPATA13
SRC
SSFA2
STAT3
STUB1
TBL1X
TJP1
TNFSF11
TUBB3
U2AF2
UBA52
UBASH3B
VAV1
WBP4
YES1
YTHDC1
ZBTB7A
ZDHHC6
Entrez ID
6907
10657
HPRD ID
02183
03926
Ensembl ID
ENSG00000101849
ENSG00000121774
Uniprot IDs
O60907
Q07666
PDB IDs
2XTC
2XTD
2XTE
2XA6
3QHE
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Chromatin Organization
Chromosome Organization
Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Type I Pneumocyte Differentiation
Nucleobase-containing Compound Metabolic Process
Lung Cell Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Notch Signaling Pathway
DNA Methylation On Cytosine
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Chromatin Silencing At RDNA
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Telomere Maintenance
Gene Expression
Regulation Of Chromosome Organization
Chromatin Modification
Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Cellular Metabolic Process
Female Courtship Behavior
DNA-templated Transcription, Initiation
Organelle Organization
Negative Regulation Of JNK Cascade
Histone H4-K20 Demethylation
Cell Cycle Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Stress-activated MAPK Cascade
Chromatin Silencing
Transcription, DNA-templated
Mitotic Cell Cycle
RNA Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Telomere Maintenance Via Telomerase
Cellular Macromolecule Biosynthetic Process
Lung Epithelial Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Fc Receptor Signaling Pathway
Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Communication
Peptidyl-tyrosine Autophosphorylation
Innate Immune Response
Signal Transduction
Immune Response-regulating Signaling Pathway
Immune Response
Endocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Locomotion
Movement Of Cell Or Subcellular Component
Cellular Response To Stimulus
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Defense Response
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Cellular Response To Peptide Hormone Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Phagocytosis
Cellular Response To Peptide
Positive Regulation Of Immune System Process
Neurotrophin Signaling Pathway
Positive Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Growth Factor
Antigen Receptor-mediated Signaling Pathway
Cell Differentiation
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Cellular Component Organization
Immune System Process
Response To Stimulus
Regulation Of Signaling
Cell Projection Organization
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Metabolic Process
Tagcloud
?
c1qdc1
cds1
crebbp
ctnnd1
cul1
customized
dner
eef2
eif2ak2
fzd2
fzd9
g93a
gastrocnemius
id2
inppl1
keep
loxl2
neuromuscular
pi3
pik3c2a
pik4ca
piki3r1
precede
presymptomatic
prkx
rac3
ripk4
snf1lk
sod1
Tagcloud (Difference)
?
c1qdc1
cds1
crebbp
ctnnd1
cul1
customized
dner
eef2
eif2ak2
fzd2
fzd9
g93a
gastrocnemius
id2
inppl1
keep
loxl2
neuromuscular
pi3
pik3c2a
pik4ca
piki3r1
precede
presymptomatic
prkx
rac3
ripk4
snf1lk
sod1
Tagcloud (Intersection)
?