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TBL1X and SKP1
Number of citations of the paper that reports this interaction (PubMedID
35831314
)
73
Data Source:
BioGRID
(biochemical)
HPRD
(in vitro, in vivo, two hybrid)
TBL1X
SKP1
Description
transducin beta like 1 X-linked
S-phase kinase associated protein 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Transcription Repressor Complex
Mitotic Spindle
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Molecular Function
Transcription Cis-regulatory Region Binding
Transcription Corepressor Activity
Protein Binding
Histone Binding
Identical Protein Binding
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Cullin Family Protein Binding
Molecular Function Activator Activity
Ubiquitin Ligase Complex Scaffold Activity
F-box Domain Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Sensory Perception Of Sound
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of Canonical Wnt Signaling Pathway
Protein Polyubiquitination
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Maintenance Of Protein Location In Nucleus
Axon Development
Protein K48-linked Ubiquitination
Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by PPARalpha
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
Cytoprotection by HMOX1
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Drugs
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
Indoleacetic acid
Diseases
GWAS
Prostate cancer (
23535732
)
Refractive error (
32231278
)
Mean platelet volume (
32888494
)
Systemic lupus erythematosus (
26502338
27399966
)
Interacting Genes
31 interacting genes:
ARL2
ARL3
CDC34
CORO2A
CTNNB1
DDB1
DLX3
DNAJB4
FOXK2
GPS2
H2AC18
H2BC21
H3C14
H4C1
H4C14
HDAC3
HP
HR
KHDRBS1
MECP2
NCOR1
NCOR2
SKP1
TAB2
TBL1XR1
TERF1
THRA
THRB
TINF2
UBE2D1
UBE2I
75 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CFLAR
CKS1B
CUL1
CUL7
DDX19B
FBH1
FBXL2
FBXL20
FBXL3
FBXL4
FBXL5
FBXL8
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO27
FBXO3
FBXO32
FBXO34
FBXO4
FBXO43
FBXO44
FBXO48
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LAMTOR5
LMO2
MED21
MEOX2
MTUS1
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
Entrez ID
6907
6500
HPRD ID
02183
03255
Ensembl ID
ENSG00000101849
ENSG00000113558
Uniprot IDs
O60907
P63208
PDB IDs
2XTC
2XTD
2XTE
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
6TTU
6VCD
6W66
6WCQ
6WNX
7B5L
7B5M
7B5R
7T1Y
7T1Z
7Z8B
7Z8T
7Z8V
7ZBW
7ZBZ
8BYA
8BYL
8CDJ
8CDK
8OR0
8OR3
8OR4
8S7D
8S7E
8UA6
8UBT
8UBU
9CB3
9JKB
9KBD
9KBF
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
DNA Binding
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Transcription Repressor Complex
Negative Regulation Of Macromolecule Metabolic Process
Chromatin Organization
Nucleus
Transcription Corepressor Activity
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Structural Constituent Of Chromatin
Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Complex
Nucleosome
Regulation Of Primary Metabolic Process
Female Courtship Behavior
Regulation Of Metabolic Process
Cellular Component Assembly
Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Thyroid Hormone Receptor Signaling Pathway
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Maintenance Of Protein Location In Nucleus
Chromatin
Lung Epithelial Cell Differentiation
Lung Cell Differentiation
Chromosome, Telomeric Region
Regulation Of Macromolecule Metabolic Process
Chromatin DNA Binding
Chromatin Binding
Chromosome
Regulation Of RNA Metabolic Process
Thyroid Hormone Binding
Negative Regulation Of JNK Cascade
Shelterin Complex
Regulation Of Thyroid Hormone Receptor Signaling Pathway
Nucleosome Assembly
Nuclear Body
Negative Regulation Of Intracellular Signal Transduction
Ubiquitin-dependent Protein Catabolic Process
Maintenance Of Protein Localization In Organelle
Modification-dependent Protein Catabolic Process
SCF Ubiquitin Ligase Complex
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteolysis Involved In Protein Catabolic Process
Protein Catabolic Process
Post-translational Protein Modification
Macromolecule Catabolic Process
Protein Metabolic Process
Proteolysis
Protein Modification Process
Ubiquitin Ligase Complex
Ubiquitin-like Ligase-substrate Adaptor Activity
Macromolecule Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Catabolic Process
Regulation Of Cell Cycle
Ubiquitin Protein Ligase Binding
Cytosol
Ubiquitin-protein Transferase Activity
Cullin-RING Ubiquitin Ligase Complex
Cytoplasm
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Glycoprotein Catabolic Process
Regulation Of DNA Metabolic Process
Cul7-RING Ubiquitin Ligase Complex
Positive Regulation Of DNA Metabolic Process
Protein K48-linked Ubiquitination
Ubiquitin Protein Ligase Activity
Regulation Of Cell Cycle Process
Regulation Of Protein Stability
Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Protein Binding
Regulation Of Protein Ubiquitination
Cellular Response To Stress
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Protein Metabolic Process
TORC1 Signaling
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