TINF2 and FKBP6

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TINF2	FKBP6
Gene Name		TERF1 (TRF1)-interacting nuclear factor 2	FK506 binding protein 6, 36kDa
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix	Synaptonemal Complex Cytoplasm Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Hsp90 Protein Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region	Protein Peptidyl-prolyl Isomerization Protein Folding Meiotic Nuclear Division Spermatogenesis Cell Differentiation Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation Chaperone-mediated Protein Folding
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	PIWI-interacting RNA (piRNA) biogenesis Regulatory RNA pathways Meiotic synapsis
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	10 interactors: ACD CCDC36 CCNK CDK5RAP3 GAPDH HSP90AA1 LZTS2 NME7 SUMO1P1 TINF2
Entrez ID		26277	8468
HPRD ID		16056	05326
Ensembl ID		ENSG00000092330	ENSG00000077800
Uniprot IDs		B4DFJ1 Q9BSI4	G3V0I2 O75344 Q7Z4T4
PDB IDs		3BQO 3BU8	3B7X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process	Telomere Assembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Regulation Of Telomere Maintenance Protein Localization To Chromosome Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Peptidyl-cysteine S-trans-nitrosylation Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Cellular Localization Protein Localization To Organelle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Protein Localization Regulation Of Protein ADP-ribosylation Regulation Of DNA Replication Intracellular Transport Positive Regulation Of DNA Metabolic Process Mitotic Cell Cycle Process Multicellular Organismal Development Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Protein Glycosylation Anatomical Structure Development Mitotic Cell Cycle Peptidyl-cysteine S-nitrosylation Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Protection From Non-homologous End Joining At Telomere Microtubule-based Process Telomere Capping Regulation Of Chromosome Organization Cellular Component Assembly Positive Regulation Of Telomerase Activity Protein Localization Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Developmental Process Protein Ufmylation Spindle Midzone Assembly Regulation Of Protein Glycosylation Regulation Of Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cell Cycle Process Regulation Of Cellular Process Microtubule Severing Negative Regulation Of Glycoprotein Metabolic Process
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates	biogenesis chaperone client duplicated encoded germ homolog hsp90 hsp90alpha isofom kingdoms knockout l1 mammals mislocalization miwi2 nucleotides paralogs pirna pirnas piwi retrotransposon retrotransposons rnas specialized testes transposon unchanged vertebrates
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates	biogenesis chaperone client duplicated encoded germ homolog hsp90 hsp90alpha isofom kingdoms knockout l1 mammals mislocalization miwi2 nucleotides paralogs pirna pirnas piwi retrotransposon retrotransposons rnas specialized testes transposon unchanged vertebrates
Tagcloud (Intersection) ?