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TBL1X and TAB2
Number of citations of the paper that reports this interaction (PubMedID
12150997
)
0
Data Source:
BioGRID
(pull down)
TBL1X
TAB2
Description
transducin beta like 1 X-linked
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Transcription Repressor Complex
Mitotic Spindle
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Molecular Function
Transcription Cis-regulatory Region Binding
Transcription Corepressor Activity
Protein Binding
Histone Binding
Identical Protein Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Binding
Metal Ion Binding
Molecular Adaptor Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Sensory Perception Of Sound
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of Canonical Wnt Signaling Pathway
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Heart Development
Response To Bacterium
Negative Regulation Of Autophagy
Response To Lipopolysaccharide
Non-canonical NF-kappaB Signal Transduction
P38MAPK Cascade
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein Kinase Activity
Protein K63-linked Ubiquitination
Pathways
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by PPARalpha
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
Cytoprotection by HMOX1
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NF-kappa-B signaling pathway
CLEC7A (Dectin-1) signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Refractive error (
32231278
)
Breast cancer (
22383897
29059683
)
Coronary artery disease (
33020668
)
Diverticulitis (
28585551
)
Dupuytren's disease (
21732829
28886342
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Interacting Genes
31 interacting genes:
ARL2
ARL3
CDC34
CORO2A
CTNNB1
DDB1
DLX3
DNAJB4
FOXK2
GPS2
H2AC18
H2BC21
H3C14
H4C1
H4C14
HDAC3
HP
HR
KHDRBS1
MECP2
NCOR1
NCOR2
SKP1
TAB2
TBL1XR1
TERF1
THRA
THRB
TINF2
UBE2D1
UBE2I
44 interacting genes:
APP
CAMK2A
CST9L
EIF2AK2
EMILIN1
ERBB4
FN1
FOSL1
GTF2I
HDAC1
HDAC3
HDAC5
HSF2BP
IKBKB
IKBKG
IRAK1
KRT85
MAP3K7
NCOR1
NFKB1
NR2C2
NUMBL
PPIL3
PPP2CB
SLC19A3
TAB1
TBL1X
TGM2
TNFRSF11A
TPM3
TRAF2
TRAF3IP1
TRAF6
TRIM45
TTN
UBC
UBE2I
VIM
VPS52
XIAP
YWHAZ
ZBTB16
ZFP64
ZNF143
Entrez ID
6907
23118
HPRD ID
02183
05483
Ensembl ID
ENSG00000101849
ENSG00000055208
Uniprot IDs
O60907
B4DIR9
Q9NYJ8
PDB IDs
2XTC
2XTD
2XTE
2DAE
2WWZ
2WX0
2WX1
9AVT
9AVW
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
DNA Binding
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Transcription Repressor Complex
Negative Regulation Of Macromolecule Metabolic Process
Chromatin Organization
Nucleus
Transcription Corepressor Activity
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Structural Constituent Of Chromatin
Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Complex
Nucleosome
Regulation Of Primary Metabolic Process
Female Courtship Behavior
Regulation Of Metabolic Process
Cellular Component Assembly
Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Thyroid Hormone Receptor Signaling Pathway
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Maintenance Of Protein Location In Nucleus
Chromatin
Lung Epithelial Cell Differentiation
Lung Cell Differentiation
Chromosome, Telomeric Region
Regulation Of Macromolecule Metabolic Process
Chromatin DNA Binding
Chromatin Binding
Chromosome
Regulation Of RNA Metabolic Process
Thyroid Hormone Binding
Negative Regulation Of JNK Cascade
Shelterin Complex
Regulation Of Thyroid Hormone Receptor Signaling Pathway
Nucleosome Assembly
Nuclear Body
Negative Regulation Of Intracellular Signal Transduction
Ubiquitin-dependent Protein Catabolic Process
Maintenance Of Protein Localization In Organelle
Modification-dependent Protein Catabolic Process
Canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Gene Expression
Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of JNK Cascade
Response To External Biotic Stimulus
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Defense Response
Positive Regulation Of Metabolic Process
Defense Response
Regulation Of Signaling
Positive Regulation Of Defense Response
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Communication
Identical Protein Binding
Regulation Of Macromolecule Metabolic Process
Protein Modification Process
Positive Regulation Of Multicellular Organismal Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Histone Deacetylase Complex
Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Negative Regulation Of Macromolecule Biosynthetic Process
Cytosol
Toll-like Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Negative Regulation Of Biosynthetic Process
Pattern Recognition Receptor Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Regulation Of DNA-templated Transcription
Innate Immune Response-activating Signaling Pathway
Response To Other Organism
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