TBL1X and DLX3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TBL1X	DLX3
Name		transducin beta like 1 X-linked	distal-less homeobox 3
Structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Chromatin Nucleus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Histone Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway	Blood Vessel Development Placenta Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gene Expression Wnt Signaling Pathway BMP Signaling Pathway Epithelial Cell Differentiation Hair Follicle Morphogenesis Hair Cell Differentiation Odontogenesis Of Dentin-containing Tooth Hair Cycle Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Hair Follicle Cell Proliferation Odontoblast Differentiation
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	None
Diseases		None	Trichodentoosseous dysplasia Amelogenesis imperfecta hypoplastic-hypomaturation with taurodontism (AIHHT)
GWAS		Prostate cancer ( 23535732 ) Refractive error ( 32231278 )	Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701 )
Novel Interactors		1 novel interactors: IQCB1	None recorded
Interacting Genes		31 interacting genes: ARL2 ARL3 CDC34 CORO2A CTNNB1 DDB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I	5 interacting genes: BANP POU4F2 PRKCA TBL1X TDP2
Entrez ID		6907	1747
HPRD ID		02183	02752
Ensembl ID		ENSG00000101849	ENSG00000064195
Uniprot IDs		O60907	O60479
PDB IDs		2XTC 2XTD 2XTE	4XRS
GO Terms Enriched among Interactors		Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Transcription Corepressor Activity Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Structural Constituent Of Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Nucleosome Regulation Of Primary Metabolic Process Female Courtship Behavior Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Chromatin Lung Epithelial Cell Differentiation Lung Cell Differentiation Chromosome, Telomeric Region Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Chromatin Binding Chromosome Regulation Of RNA Metabolic Process Thyroid Hormone Binding Negative Regulation Of JNK Cascade Shelterin Complex Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleosome Assembly Nuclear Body Negative Regulation Of Intracellular Signal Transduction Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Localization In Organelle Modification-dependent Protein Catabolic Process	Response To Estradiol Nucleoplasm Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Amacrine Cell Differentiation Axonogenesis Sensory Perception Of Mechanical Stimulus Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Myeloid Cell Differentiation Sensory Perception Of Sound Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Biosynthetic Process Nervous System Process Dorsal Root Ganglion Development Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Transcription Corepressor Activity Regulation Of Myeloid Cell Differentiation Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Desmosome Assembly Positive Regulation Of Nervous System Development Negative Regulation Of Adipose Tissue Development Neuron Projection Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding Response To Peptide Hormone Apoptotic Signaling Pathway Regulation Of Axon Guidance Mitotic Nuclear Membrane Disassembly Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Phorbol 13-acetate 12-myristate Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Bone Resorption Diacylglycerol Binding Ganglion Development Desmosome Organization Positive Regulation Of Macrophage Differentiation