TINF2 and APOBEC3F

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TINF2	APOBEC3F
Description		TERF1 interacting nuclear factor 2	apolipoprotein B mRNA editing enzyme catalytic subunit 3F
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	P-body Nucleus Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Positive Regulation Of Defense Response To Virus By Host Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Base Conversion Or Substitution Editing Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Viral Process Defense Response To Virus DNA Cytosine Deamination Antiviral Innate Immune Response
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases		Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	5 interacting genes: ACD APOBEC3G ARIH2 RNF7 TINF2
Entrez ID		26277	200316
HPRD ID		16056	16415
Ensembl ID		ENSG00000092330	ENSG00000128394
Uniprot IDs		B4DFJ1 Q9BSI4	Q8IUX4
PDB IDs		3BQO 3BU8 5XYF	3WUS 4IOU 4J4J 5HX4 5HX5 5W2M 5ZVA 5ZVB 6NIL
Enriched GO Terms of Interacting Partners?		Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate	Telomere Assembly Shelterin Complex Response To Virus Nuclear Telomere Cap Complex Protein Localization To Chromosome, Telomeric Region Telomere Capping Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Negative Regulation Of Telomere Maintenance Via Telomerase Growth Hormone Receptor Signaling Pathway Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Defense Response To Virus Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Other Organism Positive Regulation Of Telomere Maintenance Immune Response Negative Regulation Of Chromosome Organization DCTP Deaminase Activity Regulation Of DNA Biosynthetic Process Response To External Biotic Stimulus Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Regulation Of Telomere Maintenance Perinucleolar Chromocenter Telomere Organization Negative Regulation Of DNA Metabolic Process Innate Immune Response Interleukin-12 Receptor Complex Negative Regulation Of Focal Adhesion Disassembly Negative Regulation Of Cellular Component Organization Interleukin-23 Receptor Complex NEDD8 Ligase Activity DNA Metabolic Process Defense Response To Symbiont Chromosome, Telomeric Region Defense Response To Other Organism Immune System Process NEDD8 Transferase Activity Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation Phosphocreatine Biosynthetic Process Apolipoprotein B MRNA Editing Enzyme Complex Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome
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