TBL1X and CORO2A

Number of citations of the paper that reports this interaction (PubMedID 12628926)
40

Data Source:
HPRD (in vitro)

		TBL1X	CORO2A
Description		transducin beta like 1 X-linked	coronin 2A
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Brush Border Transcription Repressor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Histone Binding Identical Protein Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway	Intracellular Signal Transduction
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Refractive error ( 32231278)	Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		31 interacting genes: ARL2 ARL3 CDC34 CORO2A CTNNB1 DDB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I	12 interacting genes: AURKA BUB1 DCC DLC1 HDAC3 NRAS RB1 RSPH1 SMAD2 TBL1X TBL1XR1 UBE2I
Entrez ID		6907	7464
HPRD ID		02183	03695
Ensembl ID		ENSG00000101849	ENSG00000106789
Uniprot IDs		O60907	A8K9S3 Q92828
PDB IDs		2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?		Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Transcription Corepressor Activity Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Structural Constituent Of Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Nucleosome Regulation Of Primary Metabolic Process Female Courtship Behavior Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Chromatin Lung Epithelial Cell Differentiation Lung Cell Differentiation Chromosome, Telomeric Region Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Chromatin Binding Chromosome Regulation Of RNA Metabolic Process Thyroid Hormone Binding Negative Regulation Of JNK Cascade Shelterin Complex Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleosome Assembly Nuclear Body Negative Regulation Of Intracellular Signal Transduction Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Localization In Organelle Modification-dependent Protein Catabolic Process	Mitotic Spindle Histone Deacetylase Complex Transcription Corepressor Activity Transcription Repressor Complex Meiotic Spindle Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of DNA-templated Transcription Disordered Domain Specific Binding Negative Regulation Of RNA Biosynthetic Process Cell Division Chromatin Organization Aortic Valve Morphogenesis Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Negative Regulation Of Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Epithelial Cell Apoptotic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity Positive Regulation Of Ferroptosis Heart Valve Morphogenesis Membrane Assembly Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Cytosol Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Separation Negative Regulation Of Cell Differentiation P450-containing Electron Transport Chain Homomeric SMAD Protein Complex Ubiquitin Protein Ligase Binding Axis Specification Proteolysis Involved In Protein Catabolic Process Protein De-2-hydroxyisobutyrylase Activity Hindbrain Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Ras Protein Signal Transduction Positive Regulation Of Cell Cycle
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