MMP7 and TFPI

Number of citations of the paper that reports this interaction (PMID 10859319)
17

Data Source:
HPRD (in vitro)

		MMP7	TFPI
Gene Name		matrix metallopeptidase 7 (matrilysin, uterine)	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Organelle Membrane Anchored Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Zinc Ion Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Regulation Of Cell Proliferation Response To Drug Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity
Pathways		Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs			Coagulation factor VIIa Dalteparin
Diseases
GWAS		Prostate cancer ( 23535732)	Heart rate ( 23583979)
Protein-Protein Interactions		16 interactors: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11	10 interactors: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		4316	7035
HPRD ID		01525	01064
Ensembl ID		ENSG00000137673	ENSG00000003436
Uniprot IDs		P09237	P10646
PDB IDs		1MMP 1MMQ 1MMR 2DDY 2Y6C 2Y6D	1ADZ 1IRH 1TFX 4DTG
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Cell Motility Wound Healing Response To Wounding Immune System Process Locomotion System Development Response To Stress Movement Of Cell Or Subcellular Component Multicellular Organismal Development Organ Development Regulation Of Endopeptidase Activity Positive Regulation Of Keratinocyte Migration Anatomical Structure Development Regulation Of Peptidase Activity Blood Coagulation Hemostasis Glycosaminoglycan Catabolic Process Response To External Stimulus Response To Organic Substance Pathogenesis Response To Lipid Response To Bacterium Developmental Process Dermatan Sulfate Biosynthetic Process Regulation Of Body Fluid Levels Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Bone Resorption Regulation Of Proteolysis Response To Molecule Of Bacterial Origin Tissue Development Response To Other Organism Response To Biotic Stimulus Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Axonogenesis Defense Response Inflammatory Response Response To Stimulus Positive Regulation Of Tissue Remodeling Glycosaminoglycan Metabolic Process Response To Steroid Hormone	Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Proteolysis Locomotion Cell Migration Movement Of Cell Or Subcellular Component Protein Metabolic Process Cell Motility Wound Healing Response To Wounding Immune System Process Response To Stress Blood Coagulation Hemostasis Catabolic Process Negative Regulation Of Chemotaxis Regulation Of Body Fluid Levels Immune Response Leukocyte Migration Defense Response Endodermal Cell Differentiation Regulation Of Locomotion Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Biosynthetic Process Platelet Degranulation Negative Regulation Of CGMP-mediated Signaling Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Response To External Stimulus Positive Regulation Of Protein Kinase B Signaling Response To Stimulus Positive Regulation Of Epithelial Cell Migration Endoderm Development Negative Regulation Of Ion Transport Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Fungus Regulation Of Cytokine Biosynthetic Process Regulation Of Protein Kinase B Signaling
Tagcloud ?		a549 a549cis a549cisdkk3 adenocarcinoma betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline	antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic
Tagcloud (Difference) ?		a549 a549cis a549cisdkk3 adenocarcinoma betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline	antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic
Tagcloud (Intersection) ?