SRSF6 and SREK1

Number of citations of the paper that reports this interaction (PMID 10757789)
16

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SRSF6	SREK1
Gene Name		serine/arginine-rich splicing factor 6	splicing regulatory glutamine/lysine-rich protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nuclear Speck	Nucleoplasm Spliceosomal Complex
	Molecular Function	Nucleotide Binding RNA Binding Pre-mRNA Binding Poly(A) RNA Binding	Nucleotide Binding Poly(A) RNA Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Export From Nucleus RNA Splicing Gene Expression Regulation Of Keratinocyte Proliferation MRNA 3'-end Processing Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Cell Death Regulation Of Wound Healing	MRNA Processing RNA Splicing
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APP CLK1 LUC7L2 PPARGC1A RBM10 RNPS1 SF3B4 SREK1 SRPK1 SRSF4 TERF1 TERF2 TOE1 TRA2B	55 interactors: CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GNB2L1 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 RBM10 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B YBX1 ZRANB2
Entrez ID		6431	140890
HPRD ID		09054	18043
Ensembl ID		ENSG00000124193	ENSG00000153914
Uniprot IDs		Q13247	E5RFV3 Q8WXA9
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Gene Expression Telomere Maintenance Via Telomere Shortening Replicative Cell Aging MRNA 3'-end Processing Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Telomere Maintenance Negative Regulation Of RNA Splicing RNA-dependent DNA Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Telomere Maintenance Via Telomere Lengthening Positive Regulation Of RNA Splicing Regulation Of Chromosome Organization Termination Of RNA Polymerase II Transcription Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Cellular Response To Nitrite MRNA Export From Nucleus DNA-templated Transcription, Termination Cell Aging RNA Export From Nucleus Regulation Of RNA Metabolic Process Telomere Maintenance Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Chromosome Organization	RNA Splicing RNA Processing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Export From Nucleus Termination Of RNA Polymerase II Transcription RNA Transport MRNA Export From Nucleus RNA Localization MRNA 3'-end Processing Nuclear Export MRNA Transport Cellular Metabolic Process RNA 3'-end Processing DNA-templated Transcription, Termination Ribonucleoprotein Complex Assembly Regulation Of MRNA Stability Regulation Of RNA Stability Nucleocytoplasmic Transport Nuclear Transport Spliceosomal Complex Assembly Regulation Of Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing MRNA Stabilization Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Ribonucleoprotein Complex Biogenesis Transcription, DNA-templated Posttranscriptional Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Cytoplasmic Transport Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript
Tagcloud (Difference) ?		a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript
Tagcloud (Intersection) ?