SRSF6 and RBM10

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		SRSF6	RBM10
Gene Name		serine/arginine-rich splicing factor 6	RNA binding motif protein 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding RNA Binding Pre-mRNA Binding Poly(A) RNA Binding	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Export From Nucleus RNA Splicing Gene Expression Regulation Of Keratinocyte Proliferation MRNA 3'-end Processing Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Cell Death Regulation Of Wound Healing	MRNA Processing Biological_process RNA Splicing
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APP CLK1 LUC7L2 PPARGC1A RBM10 RNPS1 SF3B4 SREK1 SRPK1 SRSF4 TERF1 TERF2 TOE1 TRA2B	21 interactors: AES ATN1 CCAR1 CSNK2A1 DDX5 FAM124A HNRNPH2 HNRNPK IK NHP2L1 PRCC PTBP1 PTBP2 RBM4 SF1 SF3A1 SREK1 SRSF6 TBC1D22B U2AF1 UBQLN4
Entrez ID		6431	8241
HPRD ID		09054	02095
Ensembl ID		ENSG00000124193	ENSG00000182872
Uniprot IDs		Q13247	P98175 Q7Z3D7
PDB IDs			2LXI 2M2B
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Gene Expression Telomere Maintenance Via Telomere Shortening Replicative Cell Aging MRNA 3'-end Processing Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Telomere Maintenance Negative Regulation Of RNA Splicing RNA-dependent DNA Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Telomere Maintenance Via Telomere Lengthening Positive Regulation Of RNA Splicing Regulation Of Chromosome Organization Termination Of RNA Polymerase II Transcription Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Cellular Response To Nitrite MRNA Export From Nucleus DNA-templated Transcription, Termination Cell Aging RNA Export From Nucleus Regulation Of RNA Metabolic Process Telomere Maintenance Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Chromosome Organization	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing RNA Metabolic Process Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of MRNA Processing Ribonucleoprotein Complex Biogenesis MRNA 3'-splice Site Recognition Ribonucleoprotein Complex Assembly Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Termination Of RNA Polymerase II Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process MRNA Export From Nucleus Cellular Macromolecular Complex Assembly DNA-templated Transcription, Termination Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Export From Nucleus Regulation Of Metabolic Process MRNA 3'-end Processing Biosynthetic Process Primary Sex Determination Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Anoikis RNA 3'-end Processing Negative Regulation Of Biosynthetic Process IRES-dependent Translational Initiation
Tagcloud ?		a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript	abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks responder responders rin1 seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Difference) ?		a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript	abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks responder responders rin1 seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Intersection) ?