SRSF6 and TOE1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		SRSF6	TOE1
Gene Name		serine/arginine-rich splicing factor 6	target of EGR1, member 1 (nuclear)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Nucleolus Nuclear Speck
	Molecular Function	Nucleotide Binding RNA Binding Pre-mRNA Binding Poly(A) RNA Binding	Nucleic Acid Binding Protein Binding Metal Ion Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Export From Nucleus RNA Splicing Gene Expression Regulation Of Keratinocyte Proliferation MRNA 3'-end Processing Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Cell Death Regulation Of Wound Healing
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APP CLK1 LUC7L2 PPARGC1A RBM10 RNPS1 SF3B4 SREK1 SRPK1 SRSF4 TERF1 TERF2 TOE1 TRA2B	25 interactors: ABCF3 AGGF1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		6431	114034
HPRD ID		09054	18212
Ensembl ID		ENSG00000124193	ENSG00000132773
Uniprot IDs		Q13247	B4DEM6 Q96GM8
PDB IDs			2FC6
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Gene Expression Telomere Maintenance Via Telomere Shortening Replicative Cell Aging MRNA 3'-end Processing Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Telomere Maintenance Negative Regulation Of RNA Splicing RNA-dependent DNA Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Telomere Maintenance Via Telomere Lengthening Positive Regulation Of RNA Splicing Regulation Of Chromosome Organization Termination Of RNA Polymerase II Transcription Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Cellular Response To Nitrite MRNA Export From Nucleus DNA-templated Transcription, Termination Cell Aging RNA Export From Nucleus Regulation Of RNA Metabolic Process Telomere Maintenance Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Chromosome Organization	MRNA Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA 3'-end Processing RNA 3'-end Processing RNA Metabolic Process Termination Of RNA Polymerase II Transcription Gene Expression Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nuclear Export MRNA Transport Nitrogen Compound Metabolic Process RNA Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Cellular Localization Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Cytoplasmic Transport Establishment Of Localization In Cell Intracellular Transport RNA Catabolic Process Positive Regulation Of Synaptic Vesicle Priming Positive Regulation Of Synaptic Vesicle Exocytosis Interleukin-7-mediated Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Nucleocytoplasmic Transport Cellular Metabolic Process Nuclear Transport Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Norepinephrine Stimulus Regulation Of Epithelial Cell Proliferation Regulation Of MRNA Processing PML Body Organization Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of T Cell Mediated Cytotoxicity Cellular Process
Tagcloud ?		a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript
Tagcloud (Difference) ?		a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript
Tagcloud (Intersection) ?