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ACTB and SMN1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
ACTB
SMN1
Description
actin beta
survival of motor neuron 1, telomeric
Image
GO Annotations
Cellular Component
Kinetochore
Chromatin
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Adherens Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Nuclear Matrix
SWI/SNF Complex
RSC-type Complex
Lamellipodium
Axon
Cortical Cytoskeleton
Vesicle
Protein-containing Complex
Brahma Complex
NuA4 Histone Acetyltransferase Complex
Cytoplasmic Ribonucleoprotein Granule
Apical Junction Complex
Calyx Of Held
Synapse
Extracellular Exosome
Tight Junction
NpBAF Complex
NBAF Complex
Blood Microparticle
Dense Body
Schaffer Collateral - CA1 Synapse
Presynapse
Postsynaptic Actin Cytoskeleton
Glutamatergic Synapse
BBAF Complex
GBAF Complex
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Perikaryon
Gemini Of Cajal Bodies
Molecular Function
Nucleotide Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Kinesin Binding
Protein Kinase Binding
Nitric-oxide Synthase Regulator Activity
Tat Protein Binding
Nucleosomal DNA Binding
Identical Protein Binding
Tau Protein Binding
Nitric-oxide Synthase Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Transporter Regulator Activity
RNA Binding
Protein Binding
Identical Protein Binding
Biological Process
Morphogenesis Of A Polarized Epithelium
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Cytoskeleton Organization
Establishment Or Maintenance Of Cell Polarity
Axonogenesis
Positive Regulation Of Cell Population Proliferation
Substantia Nigra Development
Regulation Of Mitotic Metaphase/anaphase Transition
Adherens Junction Assembly
Maintenance Of Blood-brain Barrier
Regulation Of Apoptotic Process
Apical Protein Localization
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Cell Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of DNA-templated Transcription
Cell Motility
Regulation Of Norepinephrine Uptake
Positive Regulation Of Norepinephrine Uptake
Regulation Of Cell Cycle
Regulation Of G0 To G1 Transition
Platelet Aggregation
Protein Localization To Adherens Junction
Cellular Response To Cytochalasin B
Postsynaptic Actin Cytoskeleton Organization
Regulation Of Transepithelial Transport
Regulation Of Synaptic Vesicle Endocytosis
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Double-strand Break Repair
Positive Regulation Of Double-strand Break Repair
Regulation Of Nucleotide-excision Repair
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
Spliceosomal SnRNP Assembly
DNA-templated Transcription Termination
MRNA Processing
Nervous System Development
RNA Splicing
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
HATs acetylate histones
Prefoldin mediated transfer of substrate to CCT/TriC
Folding of actin by CCT/TriC
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
B-WICH complex positively regulates rRNA expression
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
UCH proteinases
DNA Damage Recognition in GG-NER
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
RHOF GTPase cycle
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Regulation of CDH1 Function
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of MITF-M-dependent genes involved in pigmentation
Factors involved in megakaryocyte development and platelet production
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the canonical BAF (cBAF) complex
Formation of the polybromo-BAF (pBAF) complex
Formation of the embryonic stem cell BAF (esBAF) complex
Formation of the non-canonical BAF (ncBAF) complex
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
snRNP Assembly
SARS-CoV-2 modulates host translation machinery
Drugs
Quercetin
Phenethyl Isothiocyanate
Nusinersen
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Global electrical heterogeneity phenotypes (
29622589
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lymphocyte count (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Relative hand skill in reading disability (
24068947
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32203549
)
Interacting Genes
161 interacting genes:
A2M
ABLIM1
ABRA
ACD
ACTC1
ACTG1
ALOX5
ANXA7
AQP2
AR
ARPC1B
ATF7IP
BBS4
BCL2L1
CAP1
CAPZA1
CCN2
CCT2
CCT4
CCT5
CCT8
CDC37
CDK5R2
CDKN1A
CDKN2A
CFL1
CFL2
CLIC4
CLIC6
CLNS1A
CNN2
CORO1A
CORO7
COTL1
CPNE1
CPNE2
CPNE4
CREBBP
CSNK1A1
CSNK2B
DMTN
DNASE1
DSCR9
DSTN
DUSP19
DYNLL1
EEF1A1
EHHADH
EMD
ERG
EZR
FABP4
FHL3
FLII
FXR1
GAPDH
GNA12
GSN
H2AX
HCK
HIP1R
HMMR
HNRNPAB
HNRNPD
HNRNPU
HSD17B4
HSPB2
HTR6
KHDRBS1
LASP1
LCOR
LGALS13
LINC01554
LINC02582
LMNA
LMOD1
LRRK2
LYN
MAP1B
MAP2
MAPT
MRGBP
MTNR1A
MX1
MYO18B
MYO1E
MYOC
NCALD
NCF1
NDEL1
NEBL
NOS2
NRAP
NSMAF
NT5E
NTAQ1
OGT
P2RX7
PCYT1A
PDIA2
PDLIM5
PFDN1
PFDN4
PFN1
PFN2
PHACTR4
PLD1
PLD2
PLG
POLR2A
POT1
PRKCD
PROSER2
PTN
PTPRF
RAB4A
RAC1
RAC2
RCC1
RPL10A
S100A11
SAMHD1
SCN10A
SHBG
SMAD3
SMAD9
SMARCA4
SMN1
SPTAN1
SPTB
SPTBN2
SRPK2
SSH1
SSH2
SSH3
STX4
SUMO2
SYNJ2BP
TANC1
TGM2
TINF2
TK1
TMSB4X
TMSB4XP1
TMSB4XP4
TNNI2
TPM1
TPM2
TPM3
TRIM15
TSHR
TTR
UBC
UBE2I
UBE3A
VHL
VSNL1
WASF1
WASF2
WASF3
XPO6
166 interacting genes:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
ANXA2
APLP1
ARFGAP1
ATP5F1B
ATP6V1A
BAG6
BCL2
BLOC1S6
BYSL
CARHSP1
CCDC90B
CENPB
CHTOP
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EEF1A2
EHHADH
EIF3G
EXT2
EZH2
FAM20C
FAM9B
FBL
FGB
FLAD1
FNDC11
FUBP1
FXR1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
H3-4
HADHB
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
IQUB
ITCH
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAGED1
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NEURL2
NGFR
NKIRAS2
NMT2
NRN1
NTAQ1
OSTF1
PDE4DIP
PKM
PLXNA3
POLR1C
POLR2A
POP7
PPIG
PSME1
QARS1
RBBP4
RBBP6
RBFOX2
RBM48
REX1BD
RN7SL1
RNU1-1
RNU11
RNU2-1
RNU4-1
RPL13
RPS2
RXRA
SCARNA1
SDF4
SELENOW
SEMA5B
SETDB1
SMC5
SMN2
SNORA81
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNU13
SNUPN
SP110
SPANXN2
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TERC
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
VPS28
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
Entrez ID
60
6606
HPRD ID
00032
02646
Ensembl ID
ENSG00000075624
ENSG00000172062
Uniprot IDs
P60709
Q1KLZ0
B4DP61
E7EQZ4
Q16637
PDB IDs
3BYH
3D2U
3J82
3LUE
6ANU
6ICT
6ICV
6LTJ
6MBJ
6MBK
6MBL
6NBW
6OX0
6OX1
6OX2
6OX3
6OX4
6OX5
6V62
6V63
6WK1
6WK2
7AS4
7P1H
7QJ6
7QJ9
7VDV
7W28
7W29
7Y8R
7ZTC
7ZTD
8COG
8DNH
8IB8
8OI8
8OID
8QR1
8RTT
8RTY
8RU2
8RX1
8UAU
8VRD
8VRJ
8VRK
8X15
8X19
8X1C
8XVG
8XVT
9B2Z
9C57
9C62
9C6N
9FJM
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
7W2P
7W30
Enriched GO Terms of Interacting Partners
?
Actin Binding
Regulation Of Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Organization
Regulation Of Actin Filament-based Process
Regulation Of Organelle Organization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Negative Regulation Of Supramolecular Fiber Organization
Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Actin Filament-based Process
Actin Filament Binding
Regulation Of Cellular Component Organization
Regulation Of Cellular Component Size
Actin Filament Organization
Negative Regulation Of Cytoskeleton Organization
Cytoskeleton
Negative Regulation Of Actin Filament Polymerization
Cytoplasm
Negative Regulation Of Cellular Component Organization
Cytoskeleton Organization
Supramolecular Fiber Organization
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Organelle Organization
Actin Cytoskeleton
Regulation Of Biological Quality
Negative Regulation Of Protein-containing Complex Assembly
Extracellular Exosome
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Supramolecular Fiber Organization
Cortical Actin Cytoskeleton
Regulation Of Actin Filament Depolymerization
Actin Filament
Organelle Organization
Glutamatergic Synapse
Positive Regulation Of Cellular Component Organization
Modification Of Postsynaptic Actin Cytoskeleton
Cytosol
Regulation Of Protein Localization
Regulation Of Protein Depolymerization
Negative Regulation Of Actin Filament Depolymerization
Focal Adhesion
Regulation Of Telomere Maintenance Via Telomerase
Modification Of Postsynaptic Structure
Actin Filament Capping
Postsynapse
Modification Of Synaptic Structure
Regulation Of Cellular Localization
Spliceosomal SnRNP Assembly
RNA Binding
MRNA Metabolic Process
RNA Splicing
MRNA Processing
RNA Splicing, Via Transesterification Reactions
SMN-Sm Protein Complex
RNA Processing
Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
Protein-RNA Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Metabolic Process
U2-type Precatalytic Spliceosome
Spliceosomal Complex
Lsm2-8 Complex
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
U6 SnRNP
Lsm1-7-Pat1 Complex
Nucleoplasm
Precatalytic Spliceosome
SMN Complex
U4 SnRNP
Catalytic Step 2 Spliceosome
Telomerase Holoenzyme Complex
U7 SnRNP
Macromolecule Metabolic Process
7-methylguanosine Cap Hypermethylation
Small Nuclear Ribonucleoprotein Complex
Nucleus
Gemini Of Cajal Bodies
Methylosome
U12-type Spliceosomal Complex
PICln-Sm Protein Complex
Spliceosomal Tri-snRNP Complex
Cytosol
U2 SnRNP
Spliceosomal Complex Assembly
Protein-containing Complex Assembly
U1 SnRNP
U7 SnRNA Binding
U5 SnRNP
Cytoplasm
Cajal Body
Histone Pre-mRNA DCP Binding
U2-type Prespliceosome Assembly
Protein-containing Complex Organization
U6 SnRNA Binding
Promoter-specific Chromatin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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