ACTB and NSMAF

Number of citations of the paper that reports this interaction (PMID 17599063)
10

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ACTB	NSMAF
Gene Name		actin, beta	neutral sphingomyelinase (N-SMase) activation associated factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Axon Ribonucleoprotein Complex Cortical Cytoskeleton NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Protein Complex Extracellular Vesicular Exosome MLL5-L Complex Blood Microparticle	Cytoplasm Endomembrane System Extrinsic Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Nitric-oxide Synthase Binding	Receptor Signaling Protein Activity Protein Binding Phospholipid Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Retina Homeostasis Chromatin Organization Protein Folding Movement Of Cell Or Subcellular Component Axon Guidance Blood Coagulation Substantia Nigra Development Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ATP-dependent Chromatin Remodeling Cellular Protein Metabolic Process Innate Immune Response Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway 'de Novo' Posttranslational Protein Folding Membrane Organization Platelet Aggregation	Ceramide Metabolic Process Signal Transduction Endosomal Transport Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity
Pathways		Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 HATs acetylate histones VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Folding of actin by CCT/TriC Innate Immune System Cell junction organization Protein folding Formation of annular gap junctions Chromatin organization Gap junction trafficking Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes Signaling by VEGF Chaperonin-mediated protein folding Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		138 interactors: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAP2 CAPZA1 CCT2 CCT4 CCT5 CCT8 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CSNK1A1 CSNK2B CTGF DMTN DNASE1 DSTN DYNLL1 EEF1A1 EHHADH EMD EP300 ERG EZR FABP4 FHL3 FLII GAPDH GNA12 GSN H2AFX HCK HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 KHDRBS1 LASP1 LGALS13 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MX1 MYO18B MYO1E MYOC NCALD NCF1 NCF2 NEBL NOS2 NRAP NSMAF NT5E P2RX7 PCYT1A PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTBN2 SSH1 SSH2 SSH3 STX4 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TTR VHL VSNL1 WASF1 WASF2 WASF3 WDYHV1 XPO6	4 interactors: ACTB CD40 GNB2L1 TNFRSF1A
Entrez ID		60	8439
HPRD ID		00032	09117
Ensembl ID		ENSG00000075624	ENSG00000035681
Uniprot IDs		B3KWQ3 P60709 Q1KLZ0	Q92636
PDB IDs		3BYH 3D2U 3LUE
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Organelle Organization Regulation Of Cellular Component Size Developmental Process Cell Differentiation Anatomical Structure Development Cell Development Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Filament Polymerization Actin Filament Organization Positive Regulation Of Organelle Organization System Development Negative Regulation Of Actin Filament Polymerization Regulation Of Cell Morphogenesis Multicellular Organismal Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Protein Complex Assembly Regulation Of Cell Projection Assembly Cellular Component Assembly Cellular Process Movement Of Cell Or Subcellular Component Regulation Of Cell Projection Organization Regulation Of Lamellipodium Assembly Platelet Activation Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Complex Assembly Regulation Of Cellular Process Cell Morphogenesis Wound Healing Positive Regulation Of Cellular Component Biogenesis Response To Wounding Regulation Of Stress Fiber Assembly Hemostasis Response To Stimulus Cell Death Death Positive Regulation Of Stress Fiber Assembly Apoptotic Process Cell Projection Organization	Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of JAK-STAT Cascade Regulation Of Establishment Of Protein Localization Response To Wounding Positive Regulation Of Protein Phosphorylation Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Response To Mechanical Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Phosphorylation Defense Response Regulation Of Neuron Death Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Isotype Switching To IgG Isotypes Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Regulation Of Isotype Switching To IgG Isotypes Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Tagcloud ?		18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid	alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic
Tagcloud (Difference) ?		18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid	alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic
Tagcloud (Intersection) ?