ACTB and PFDN4

Number of citations: 60 (PubMedID 12456645)
Data Source: HPRD (in vivo, in vitro)

		ACTB	PFDN4
Name		actin beta	prefoldin subunit 4
Structure
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction NpBAF Complex NBAF Complex Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse BBAF Complex GBAF Complex Ribonucleoprotein Complex	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Transporter Regulator Activity	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Morphogenesis Of A Polarized Epithelium Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Axonogenesis Positive Regulation Of Cell Population Proliferation Substantia Nigra Development Regulation Of Mitotic Metaphase/anaphase Transition Adherens Junction Assembly Maintenance Of Blood-brain Barrier Regulation Of Apoptotic Process Apical Protein Localization Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle Regulation Of G0 To G1 Transition Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs		Quercetin Phenethyl Isothiocyanate	None
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	None
GWAS		Global electrical heterogeneity phenotypes ( 29622589 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Relative hand skill in reading disability ( 24068947 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Triglyceride levels ( 32203549 )	Atopic dermatitis ( 23042114 ) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297 ) Creatinine levels ( 31015462 ) HDL cholesterol levels in HIV infection ( 33109212 ) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945 ) Obesity-related traits ( 23251661 )
Novel Interactors		2 novel interactors: RALA TCF12	None recorded
Interacting Genes		161 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDC37 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLIC6 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CREBBP CSNK1A1 CSNK2B DMTN DNASE1 DSCR9 DSTN DUSP19 DYNLL1 EEF1A1 EHHADH EMD ERG EZR FABP4 FHL3 FLII FXR1 GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 HTR6 KHDRBS1 LASP1 LCOR LGALS13 LINC01554 LINC02582 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 OGT P2RX7 PCYT1A PDIA2 PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SUMO2 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TSHR TTR UBC UBE2I UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6	6 interacting genes: ACTB ERBB3 PFDN2 RFPL3 TUBA4A TUBB
Entrez ID		60	5203
HPRD ID		00032	05358
Ensembl ID		ENSG00000075624	ENSG00000101132
Uniprot IDs		P60709 Q1KLZ0	Q9NQP4
PDB IDs		3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6LTJ 6MBJ 6MBK 6MBL 6NBW 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7AS4 7P1H 7QJ6 7QJ9 7VDV 7W28 7W29 7Y8R 7ZTC 7ZTD 8COG 8DNH 8IB8 8OI8 8OID 8QR1 8RTT 8RTY 8RU2 8RX1 8UAU 8VRD 8VRJ 8VRK 8X15 8X19 8X1C 8XVG 8XVT 9B2Z 9C57 9C62 9C6N 9FJM	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
GO Terms Enriched among Interactors		Actin Binding Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Supramolecular Fiber Organization Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Actin Filament Binding Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Actin Filament Organization Negative Regulation Of Cytoskeleton Organization Cytoskeleton Negative Regulation Of Actin Filament Polymerization Cytoplasm Negative Regulation Of Cellular Component Organization Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Regulation Of Biological Quality Negative Regulation Of Protein-containing Complex Assembly Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cortical Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Actin Filament Organelle Organization Glutamatergic Synapse Positive Regulation Of Cellular Component Organization Modification Of Postsynaptic Actin Cytoskeleton Cytosol Regulation Of Protein Localization Regulation Of Protein Depolymerization Negative Regulation Of Actin Filament Depolymerization Focal Adhesion Regulation Of Telomere Maintenance Via Telomerase Modification Of Postsynaptic Structure Actin Filament Capping Postsynapse Modification Of Synaptic Structure Regulation Of Cellular Localization	Structural Constituent Of Cytoskeleton Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Norepinephrine Uptake Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Nucleotide Binding Regulation Of Transepithelial Transport Protein-containing Complex Protein Localization To Adherens Junction Dense Body Transporter Regulator Activity ErbB-3 Class Receptor Binding Neuregulin Receptor Activity Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Mitotic Cell Cycle Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Schwann Cell Differentiation Prefoldin Complex Odontoblast Differentiation BBAF Complex Tat Protein Binding Nitric-oxide Synthase Regulator Activity Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Negative Regulation Of Motor Neuron Apoptotic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway RPAP3/R2TP/prefoldin-like Complex Microtubule Cytoskeleton GTPase Activating Protein Binding Nuclear Envelope Lumen Brahma Complex Nitric-oxide Synthase Binding NBAF Complex Apical Protein Localization RSC-type Complex Adherens Junction Assembly Postsynaptic Actin Cytoskeleton Organization NpBAF Complex GBAF Complex Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Protein Tyrosine Kinase Activator Activity Endocardial Cushion Development Ubiquitin Protein Ligase Binding Negative Regulation Of Amyloid Fibril Formation