ACTB and TTR

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ACTB	TTR
Gene Name		actin, beta	transthyretin
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Axon Ribonucleoprotein Complex Cortical Cytoskeleton NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Protein Complex Extracellular Vesicular Exosome MLL5-L Complex Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Nitric-oxide Synthase Binding	Hormone Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity Thyroid Hormone Binding
	Biological Process	Retina Homeostasis Chromatin Organization Protein Folding Movement Of Cell Or Subcellular Component Axon Guidance Blood Coagulation Substantia Nigra Development Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ATP-dependent Chromatin Remodeling Cellular Protein Metabolic Process Innate Immune Response Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway 'de Novo' Posttranslational Protein Folding Membrane Organization Platelet Aggregation	Retinoid Metabolic Process Transport Phototransduction, Visible Light Extracellular Matrix Organization Retinol Metabolic Process Thyroid Hormone Transport
Pathways		Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 HATs acetylate histones VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Folding of actin by CCT/TriC Innate Immune System Cell junction organization Protein folding Formation of annular gap junctions Chromatin organization Gap junction trafficking Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes Signaling by VEGF Chaperonin-mediated protein folding Cell-extracellular matrix interactions	Amyloids Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Non-integrin membrane-ECM interactions Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Retinol levels ( 21878437)
Protein-Protein Interactions		138 interactors: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAP2 CAPZA1 CCT2 CCT4 CCT5 CCT8 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CSNK1A1 CSNK2B CTGF DMTN DNASE1 DSTN DYNLL1 EEF1A1 EHHADH EMD EP300 ERG EZR FABP4 FHL3 FLII GAPDH GNA12 GSN H2AFX HCK HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 KHDRBS1 LASP1 LGALS13 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MX1 MYO18B MYO1E MYOC NCALD NCF1 NCF2 NEBL NOS2 NRAP NSMAF NT5E P2RX7 PCYT1A PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTBN2 SSH1 SSH2 SSH3 STX4 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TTR VHL VSNL1 WASF1 WASF2 WASF3 WDYHV1 XPO6	46 interactors: A2M ACTB AGER APOA1 ASNA1 ATF4 BAG6 C14orf1 CDR2 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 FEZ1 GET4 HNRNPH3 HSPG2 IKBKAP INPP5K KIAA1377 LRP2 MARK3 MT3 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1
Entrez ID		60	7276
HPRD ID		00032	01447
Ensembl ID		ENSG00000075624	ENSG00000118271
Uniprot IDs		B3KWQ3 P60709 Q1KLZ0	E9KL36 P02766
PDB IDs		3BYH 3D2U 3LUE	1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 5TTR
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Organelle Organization Regulation Of Cellular Component Size Developmental Process Cell Differentiation Anatomical Structure Development Cell Development Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Filament Polymerization Actin Filament Organization Positive Regulation Of Organelle Organization System Development Negative Regulation Of Actin Filament Polymerization Regulation Of Cell Morphogenesis Multicellular Organismal Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Protein Complex Assembly Regulation Of Cell Projection Assembly Cellular Component Assembly Cellular Process Movement Of Cell Or Subcellular Component Regulation Of Cell Projection Organization Regulation Of Lamellipodium Assembly Platelet Activation Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Complex Assembly Regulation Of Cellular Process Cell Morphogenesis Wound Healing Positive Regulation Of Cellular Component Biogenesis Response To Wounding Regulation Of Stress Fiber Assembly Hemostasis Response To Stimulus Cell Death Death Positive Regulation Of Stress Fiber Assembly Apoptotic Process Cell Projection Organization	Protein Insertion Into ER Membrane Anatomical Structure Development Developmental Process Protein Stabilization Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Protein Stability Nervous System Development Central Nervous System Development Regulation Of Gene Expression Protein Insertion Into Membrane System Development Cellular Localization Phototransduction, Visible Light Retinoid Metabolic Process Detection Of Abiotic Stimulus Diterpenoid Metabolic Process Detection Of Visible Light Cellular Response To Stimulus Platelet Activation Phototransduction Response To Light Stimulus Chromatin Organization Regulation Of Glucose Transport Alcohol Metabolic Process Detection Of Light Stimulus Organelle Organization Establishment Of Protein Localization To Membrane Metabolic Process Lipid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Cellular Metabolic Process Isoprenoid Metabolic Process Response To Organic Substance Endoplasmic Reticulum Organization Chromatin Modification Regulation Of Cellular Protein Metabolic Process Membrane Organization Response To Radiation Negative Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Response To Wounding Signaling Regulation Of Glucose Import Cellular Protein Modification Process
Tagcloud ?		18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Difference) ?		18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Intersection) ?