ACTB and PFDN1

Number of citations of the paper that reports this interaction (PMID 11535601)
6

Data Source:
HPRD (in vitro, in vivo)

		ACTB	PFDN1
Gene Name		actin, beta	prefoldin subunit 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Axon Ribonucleoprotein Complex Cortical Cytoskeleton NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Protein Complex Extracellular Vesicular Exosome MLL5-L Complex Blood Microparticle	Prefoldin Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Nitric-oxide Synthase Binding	Sequence-specific DNA Binding Transcription Factor Activity Unfolded Protein Binding
	Biological Process	Retina Homeostasis Chromatin Organization Protein Folding Movement Of Cell Or Subcellular Component Axon Guidance Blood Coagulation Substantia Nigra Development Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ATP-dependent Chromatin Remodeling Cellular Protein Metabolic Process Innate Immune Response Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway 'de Novo' Posttranslational Protein Folding Membrane Organization Platelet Aggregation	Regulation Of Transcription, DNA-templated Protein Folding Cell Cycle Telencephalon Development Cerebellum Development Actin Cytoskeleton Organization B Cell Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding
Pathways		Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 HATs acetylate histones VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Folding of actin by CCT/TriC Innate Immune System Cell junction organization Protein folding Formation of annular gap junctions Chromatin organization Gap junction trafficking Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes Signaling by VEGF Chaperonin-mediated protein folding Cell-extracellular matrix interactions	Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding
Drugs
Diseases
GWAS
Protein-Protein Interactions		138 interactors: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAP2 CAPZA1 CCT2 CCT4 CCT5 CCT8 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CSNK1A1 CSNK2B CTGF DMTN DNASE1 DSTN DYNLL1 EEF1A1 EHHADH EMD EP300 ERG EZR FABP4 FHL3 FLII GAPDH GNA12 GSN H2AFX HCK HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 KHDRBS1 LASP1 LGALS13 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MX1 MYO18B MYO1E MYOC NCALD NCF1 NCF2 NEBL NOS2 NRAP NSMAF NT5E P2RX7 PCYT1A PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTBN2 SSH1 SSH2 SSH3 STX4 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TTR VHL VSNL1 WASF1 WASF2 WASF3 WDYHV1 XPO6	54 interactors: ACTA1 ACTB ALB ASNA1 BRK1 CCDC85A CHGA DCTN1 DEFA1 DGCR14 EDRF1 EIF3C EIF4A2 EOMES EXT2 EZH2 FAM20C GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 KIAA1377 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 TUBA1A YEATS4 ZNF235
Entrez ID		60	5201
HPRD ID		00032	05357
Ensembl ID		ENSG00000075624	ENSG00000113068
Uniprot IDs		B3KWQ3 P60709 Q1KLZ0	O60925
PDB IDs		3BYH 3D2U 3LUE
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Organelle Organization Regulation Of Cellular Component Size Developmental Process Cell Differentiation Anatomical Structure Development Cell Development Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Filament Polymerization Actin Filament Organization Positive Regulation Of Organelle Organization System Development Negative Regulation Of Actin Filament Polymerization Regulation Of Cell Morphogenesis Multicellular Organismal Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Protein Complex Assembly Regulation Of Cell Projection Assembly Cellular Component Assembly Cellular Process Movement Of Cell Or Subcellular Component Regulation Of Cell Projection Organization Regulation Of Lamellipodium Assembly Platelet Activation Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Complex Assembly Regulation Of Cellular Process Cell Morphogenesis Wound Healing Positive Regulation Of Cellular Component Biogenesis Response To Wounding Regulation Of Stress Fiber Assembly Hemostasis Response To Stimulus Cell Death Death Positive Regulation Of Stress Fiber Assembly Apoptotic Process Cell Projection Organization	Organelle Organization Cellular Localization Cellular Macromolecule Biosynthetic Process Cellular Component Assembly Macromolecule Biosynthetic Process Gene Expression Membrane Organization RNA Biosynthetic Process Cellular Protein Localization Establishment Of Protein Localization To Membrane Protein Localization Developmental Process Cerebral Cortex Regionalization Mitotic Cell Cycle Biosynthetic Process Cellular Process Cytoskeleton-dependent Intracellular Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Metabolic Process Establishment Of Localization In Cell Anatomical Structure Development RNA Metabolic Process Organelle Localization 'de Novo' Posttranslational Protein Folding Intracellular Transport Cell Cycle Process 'de Novo' Protein Folding Regulation Of Metabolic Process Telencephalon Regionalization Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Protein Localization To Organelle Positive Regulation Of Cellular Metabolic Process Protein Localization To Membrane Vesicle Localization Regulation Of Cilium Assembly Multicellular Organismal Development Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Phase Transition Anatomical Structure Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Killing Of Cells Of Other Organism Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Anatomical Structure Formation Involved In Morphogenesis
Tagcloud ?		18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid
Tagcloud (Difference) ?		18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid
Tagcloud (Intersection) ?