ACTB and VHL

Number of citations of the paper that reports this interaction (PubMedID 22234250)
29

Data Source:
BioGRID (pull down)

		ACTB	VHL
Description		actin beta	von Hippel-Lindau tumor suppressor
Image
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction NpBAF Complex NBAF Complex Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse BBAF Complex GBAF Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Membrane
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Transporter Regulator Activity	Transcription Elongation Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Morphogenesis Of A Polarized Epithelium Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Axonogenesis Positive Regulation Of Cell Population Proliferation Substantia Nigra Development Regulation Of Mitotic Metaphase/anaphase Transition Adherens Junction Assembly Maintenance Of Blood-brain Barrier Regulation Of Apoptotic Process Apical Protein Localization Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle Regulation Of G0 To G1 Transition Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Response To Hypoxia Regulation Of DNA-templated Transcription Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Cellular Response To Hypoxia Regulation Of Cellular Response To Hypoxia Negative Regulation Of TORC1 Signaling Amyloid Fibril Formation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Quercetin Phenethyl Isothiocyanate
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma
GWAS		Global electrical heterogeneity phenotypes ( 29622589) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Relative hand skill in reading disability ( 24068947) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)	Bullous pemphigoid ( 34011352) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		161 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDC37 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLIC6 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CREBBP CSNK1A1 CSNK2B DMTN DNASE1 DSCR9 DSTN DUSP19 DYNLL1 EEF1A1 EHHADH EMD ERG EZR FABP4 FHL3 FLII FXR1 GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 HTR6 KHDRBS1 LASP1 LCOR LGALS13 LINC01554 LINC02582 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 OGT P2RX7 PCYT1A PDIA2 PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SUMO2 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TSHR TTR UBC UBE2I UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6	172 interacting genes: ACTB AHI1 AKT1 ANKEF1 ANKRD11 APP ARHGEF7 AURKA BEX2 BEX4 BRCA1 BRD4 CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CCT5 CCT7 CD44 CDC34 CDK1 CDK5RAP3 CDKN2A CERKL CHEK2 CLU COL4A2 COMMD1 CPNE5 CSNK2A1 CUL2 CUL5 DGKI DIDO1 DNAJA3 DSTN DVL2 E2F1 EEF1A1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR ERI1 ETFA FBXO28 FBXO34 FKBP8 FLNA FLOT1 FN1 GHET1 GPANK1 GPS1 GTF3C2 GUK1 H1-2 H2BC13 H4C16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IFT88 IKBKB ITPKC JADE1 KIF2C KIF3A KLF4 KLHL10 LANCL1 MAP1B MAP1LC3B MAP1S MDFI MRPS9 MSL2 MT-CO2 NCL NISCH NR4A1 NR4A2 NR4A3 NSUN5 NSUN7 OTUD6B PAX2 PDCD5 PFKP PHB2 PIAS4 PIWIL4 PKP2 PLD1 PLD2 POLR2G PPP1R13L PPP5C PRDX1 PRKCI PRKG1 PRMT1 PRMT8 PSMC1 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RERE RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SAP30 SARNP SAT2 SELENOP SETDB1 SKP2 SLC2A1 SLC3A2 SMC5 SNRNP200 SON SP1 SPARC SPATA22 SPZ1 STAMBP SUV39H2 TBK1 TDRD7 TEX35 TPT1 TRIM28 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2I USP20 USP33 USP9X UXT VAPB VBP1 VRK1 WSB1 YY1AP1 ZBTB17 ZNF197 ZNF200 ZNF512B ZNF668 ZNF827
Entrez ID		60	7428
HPRD ID		00032	01905
Ensembl ID		ENSG00000075624	ENSG00000134086
Uniprot IDs		P60709 Q1KLZ0	A0A024R2F2 A0A0S2Z4K1 A0A8Q3WL21 P40337
PDB IDs		3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6LTJ 6MBJ 6MBK 6MBL 6NBW 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7AS4 7P1H 7QJ6 7QJ9 7VDV 7W28 7W29 7Y8R 7ZTC 7ZTD 8COG 8DNH 8IB8 8OI8 8OID 8QR1 8RTT 8RTY 8RU2 8RX1 8UAU 8VRD 8VRJ 8VRK 8X15 8X19 8X1C 8XVG 8XVT 9B2Z 9C57 9C62 9C6N 9FJM	1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC 7CJB 7JTO 7JTP 7KHH 7PI4 7Q2J 7S4E 7Z6L 7Z76 7Z77 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8EI3 8EWV 8FY0 8FY1 8FY2 8G1P 8G1Q 8P0F 8PC2 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8VL9 8VLB 8WDK 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9EQJ 9EQM 9IPW
Enriched GO Terms of Interacting Partners?		Actin Binding Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Supramolecular Fiber Organization Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Actin Filament Binding Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Actin Filament Organization Negative Regulation Of Cytoskeleton Organization Cytoskeleton Negative Regulation Of Actin Filament Polymerization Cytoplasm Negative Regulation Of Cellular Component Organization Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Regulation Of Biological Quality Negative Regulation Of Protein-containing Complex Assembly Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cortical Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Actin Filament Organelle Organization Glutamatergic Synapse Positive Regulation Of Cellular Component Organization Modification Of Postsynaptic Actin Cytoskeleton Cytosol Regulation Of Protein Localization Regulation Of Protein Depolymerization Negative Regulation Of Actin Filament Depolymerization Focal Adhesion Regulation Of Telomere Maintenance Via Telomerase Modification Of Postsynaptic Structure Actin Filament Capping Postsynapse Modification Of Synaptic Structure Regulation Of Cellular Localization	Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Cytosol Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Macromolecule Metabolic Process Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Stability Chromatin Remodeling Positive Regulation Of Biosynthetic Process NF-kappaB Binding Response To Stress Negative Regulation Of Apoptotic Process Intracellular Signal Transduction
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