ACTB and RAC1

Number of citations: 0 (PubMedID 11027608)
Data Source: HPRD (in vitro, in vivo)

		ACTB	RAC1
Name		actin beta	Rac family small GTPase 1
Structure
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction NpBAF Complex NBAF Complex Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse BBAF Complex GBAF Complex Ribonucleoprotein Complex	Pericentriolar Material Phagocytic Cup Nucleus Cytoplasm Endoplasmic Reticulum Membrane Trans-Golgi Network Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Membrane Lamellipodium Dendrite Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Ruffle Membrane Cytoplasmic Ribonucleoprotein Granule Melanosome Presynaptic Membrane Cell Projection NADPH Oxidase Complex Synapse Postsynaptic Membrane Recycling Endosome Membrane Kinocilium Extracellular Exosome Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Transporter Regulator Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding Protein-containing Complex Binding Rho GDP-dissociation Inhibitor Binding
	Biological Process	Morphogenesis Of A Polarized Epithelium Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Axonogenesis Positive Regulation Of Cell Population Proliferation Substantia Nigra Development Regulation Of Mitotic Metaphase/anaphase Transition Adherens Junction Assembly Maintenance Of Blood-brain Barrier Regulation Of Apoptotic Process Apical Protein Localization Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle Regulation Of G0 To G1 Transition Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Neuron Migration Positive Regulation Of Protein Phosphorylation Auditory Receptor Cell Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Epithelial Cell Morphogenesis Endocytosis Phagocytosis, Engulfment Inflammatory Response Hyperosmotic Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Enzyme-linked Receptor Protein Signaling Pathway G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Axon Guidance Motor Neuron Axon Guidance Regulation Of Cell Shape Response To Wounding Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Endothelial Cell Migration Regulation Of Fibroblast Migration Negative Regulation Of Fibroblast Migration Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Neuron Maturation Dendrite Development Cell Migration Rac Protein Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Cell Morphogenesis Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Cortical Cytoskeleton Organization Forebrain Development Positive Regulation Of Microtubule Polymerization Ruffle Organization Response To Lipopolysaccharide Negative Regulation Of Interleukin-23 Production Regulation Of Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Superoxide Anion Generation Erythrocyte Enucleation Engulfment Of Apoptotic Cell Cell-cell Junction Organization Regulation Of Nitric Oxide Biosynthetic Process Respiratory Burst Regulation Of Receptor Signaling Pathway Via JAK-STAT Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Receptor-mediated Endocytosis Anatomical Structure Arrangement Neuron Projection Morphogenesis Dendrite Morphogenesis Cell Motility Homeostasis Of Number Of Cells Within A Tissue Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synaptic Transmission, GABAergic Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Respiratory Burst Cell Chemotaxis Positive Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of ERK5 Cascade Semaphorin-plexin Signaling Pathway Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Angiotensin-activated Signaling Pathway Involved In Heart Process Positive Regulation Of Neutrophil Chemotaxis Cochlea Morphogenesis Ruffle Assembly Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Endocytosis Regulation Of Neutrophil Migration Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Interneuron Migration Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Ovarian Follicle Development Regulation Of Neuron Migration
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production
Drugs		Quercetin Phenethyl Isothiocyanate	Dextromethorphan Azathioprine Guanosine-5'-Diphosphate
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	None
GWAS		Global electrical heterogeneity phenotypes ( 29622589 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Relative hand skill in reading disability ( 24068947 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Triglyceride levels ( 32203549 )	Apolipoprotein A1 levels ( 32203549 ) Basal cell carcinoma ( 31174203 ) Body mass index ( 26426971 ) Coronary artery disease ( 29212778 ) Keratinocyte cancer (MTAG) ( 31174203 ) LDL cholesterol levels ( 32203549 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Red cell distribution width ( 27863252 )
Interacting Genes		161 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDC37 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLIC6 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CREBBP CSNK1A1 CSNK2B DMTN DNASE1 DSCR9 DSTN DUSP19 DYNLL1 EEF1A1 EHHADH EMD ERG EZR FABP4 FHL3 FLII FXR1 GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 HTR6 KHDRBS1 LASP1 LCOR LGALS13 LINC01554 LINC02582 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 OGT P2RX7 PCYT1A PDIA2 PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SUMO2 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TSHR TTR UBC UBE2I UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6	184 interacting genes: ACTA1 ACTB AGAP1 AGAP2 AKT1 ARAP1 ARAP2 ARFIP2 ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP44 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42BPG CDC42SE1 CDC42SE2 CEBPA CFAP36 CHN1 CHN2 CIT COG5 CORO1C CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DNMBP DOCK1 DOCK2 DOCK3 DOCK7 DOCK8 DVL1 DVL2 EIF2AK2 ENAH FAM13A FAM13B FGD5 FHOD1 FLNA FMN2 FMNL1 GMIP GRIA2 GRN HACD3 HACE1 HDAC7 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KPNA4 KPNA6 KRT40 KTN1 LATS1 LRP2 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2 MCF2L MCM3AP MDFI METAP2 MT-CO3 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 NR2C2 OCRL OPHN1 PAK1 PAK2 PAK3 PAK5 PARD6A PARD6B PARD6G PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG1 PLEKHG2 PLEKHG6 PLXNA1 PLXNB1 PPP2R2B PREX1 PREX2 PRKCA PRKCD PRKCI PRKN PRMT6 PTK2 RACGAP1 RALBP1 RAP1GDS1 RASGRF1 RASGRF2 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 SNCA SNX31 SRGAP1 SRGAP3 STAT1 STAT3 STAU1 SYDE2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIM72 TRIO TUBA4A UBC UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1
Entrez ID		60	5879
HPRD ID		00032	03627
Ensembl ID		ENSG00000075624	ENSG00000136238
Uniprot IDs		P60709 Q1KLZ0	A4D2P0 A4D2P1 P63000
PDB IDs		3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6LTJ 6MBJ 6MBK 6MBL 6NBW 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7AS4 7P1H 7QJ6 7QJ9 7VDV 7W28 7W29 7Y8R 7ZTC 7ZTD 8COG 8DNH 8IB8 8OI8 8OID 8QR1 8RTT 8RTY 8RU2 8RX1 8UAU 8VRD 8VRJ 8VRK 8X15 8X19 8X1C 8XVG 8XVT 9B2Z 9C57 9C62 9C6N 9FJM	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 6AGP 6BC1 6TGC 6X1G 7AJK 7DPA 7SJ4 7USD 7USE 8I5V 8I5W 8Q0N 8WEJ 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM
GO Terms Enriched among Interactors		Actin Binding Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Supramolecular Fiber Organization Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Actin Filament Binding Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Actin Filament Organization Negative Regulation Of Cytoskeleton Organization Cytoskeleton Negative Regulation Of Actin Filament Polymerization Cytoplasm Negative Regulation Of Cellular Component Organization Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Regulation Of Biological Quality Negative Regulation Of Protein-containing Complex Assembly Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cortical Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Actin Filament Organelle Organization Glutamatergic Synapse Positive Regulation Of Cellular Component Organization Modification Of Postsynaptic Actin Cytoskeleton Cytosol Regulation Of Protein Localization Regulation Of Protein Depolymerization Negative Regulation Of Actin Filament Depolymerization Focal Adhesion Regulation Of Telomere Maintenance Via Telomerase Modification Of Postsynaptic Structure Actin Filament Capping Postsynapse Modification Of Synaptic Structure Regulation Of Cellular Localization	Regulation Of Small GTPase Mediated Signal Transduction GTPase Activator Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Intracellular Signaling Cassette Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signal Transduction Guanyl-nucleotide Exchange Factor Activity Regulation Of Cellular Component Organization Cytoplasm Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Plasma Membrane Regulation Of Organelle Organization Cell Cortex Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Regulation Of Cell Projection Organization Glutamatergic Synapse Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Rho Protein Signal Transduction Actin Filament Organization Cell Projection Organization Regulation Of Anatomical Structure Morphogenesis Supramolecular Fiber Organization Regulation Of Developmental Process Postsynapse Regulation Of Synapse Organization SH3 Domain Binding Regulation Of Cell Morphogenesis Positive Regulation Of Signaling Cell Projection Positive Regulation Of Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Communication Ruffle Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Lamellipodium Regulation Of Cell Shape Cell Migration Regulation Of Biological Quality Lamellipodium Organization