FLNA and ITGB6

Number of citations of the paper that reports this interaction (PMID 11807098)
25

Data Source:
BioGRID (two hybrid)

		FLNA	ITGB6
Gene Name		filamin A, alpha	integrin, beta 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cortical Cytoskeleton Myb Complex Neuronal Cell Body Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Apical Dendrite	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding Ral GTPase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Poly(A) RNA Binding SMAD Binding Rac GTPase Binding Actin Filament Binding	Virus Receptor Activity Integrin Binding
	Biological Process	Epithelial To Mesenchymal Transition Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation Platelet Activation Actin Cytoskeleton Reorganization Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Cilium Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Early Endosome To Late Endosome Transport Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Platelet Aggregation Mitotic Spindle Assembly	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Multicellular Organismal Development Response To Virus Viral Process Extracellular Matrix Organization
Pathways		Cell junction organization GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell-extracellular matrix interactions	Molecules associated with elastic fibres Elastic fibre formation ECM proteoglycans Integrin cell surface interactions
Drugs
Diseases
GWAS			Nephropathy (idiopathic membranous) ( 21323541) Type 2 diabetes ( 20418489)
Protein-Protein Interactions		82 interactors: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FAM101A FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MTNR1A MTNR1B MYOT NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RHOA SELE SH2B3 SHBG SIGLEC10 SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	8 interactors: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN
Entrez ID		2316	3694
HPRD ID		02060	00947
Ensembl ID		ENSG00000196924	ENSG00000115221
Uniprot IDs		P21333 Q60FE5 Q6NXF2	B4E2B8 C9JA97 E9PEE8 P18564
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH	1LH9
Enriched GO Terms of Interacting Partners?		Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Stress Regulation Of Phosphorus Metabolic Process Wound Healing Response To Wounding Regulation Of Signaling Positive Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Response To External Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Response To Abiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Tissue Development Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Multicellular Organismal Development System Development Cellular Response To Organic Substance Regulation Of Apoptotic Process Developmental Process	Tissue Development Endoderm Development Blood Coagulation Hemostasis Cell Differentiation Endodermal Cell Differentiation Platelet Activation Regulation Of Body Fluid Levels Wound Healing Endoderm Formation Anatomical Structure Morphogenesis Response To Wounding Vesicle-mediated Transport Cell Morphogenesis Involved In Differentiation Platelet Degranulation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Multicellular Organismal Development Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Vesicle-mediated Transport Cell Development Anatomical Structure Formation Involved In Morphogenesis Developmental Process Cell Morphogenesis Formation Of Primary Germ Layer Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade Regulation Of Protein Metabolic Process Cell Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Endocytosis Gastrulation Regulation Of Cell Motility System Development Cell-substrate Adhesion Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement MAPK Cascade Positive Regulation Of Transport Lipopolysaccharide-mediated Signaling Pathway Signal Transduction By Phosphorylation Substrate Adhesion-dependent Cell Spreading Cardiovascular System Development Negative Regulation Of Protein Metabolic Process
Tagcloud ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	adhesion agilent bioinformatics cdc14a cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Difference) ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	adhesion agilent bioinformatics cdc14a cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Intersection) ?