FLNA and RALA

Number of citations of the paper that reports this interaction (PMID 10051605)
91

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		FLNA	RALA
Gene Name		filamin A, alpha	v-ral simian leukemia viral oncogene homolog A (ras related)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cortical Cytoskeleton Myb Complex Neuronal Cell Body Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Apical Dendrite	Plasma Membrane Focal Adhesion Cell Surface Endocytic Vesicle Midbody Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding Ral GTPase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Poly(A) RNA Binding SMAD Binding Rac GTPase Binding Actin Filament Binding	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding
	Biological Process	Epithelial To Mesenchymal Transition Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation Platelet Activation Actin Cytoskeleton Reorganization Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Cilium Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Early Endosome To Late Endosome Transport Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Platelet Aggregation Mitotic Spindle Assembly	Cytokinesis Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Viral Process Regulation Of Exocytosis Actin Cytoskeleton Reorganization Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Membrane Raft Localization Membrane Organization
Pathways		Cell junction organization GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell-extracellular matrix interactions	Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events Translocation of GLUT4 to the plasma membrane NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		82 interactors: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FAM101A FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MTNR1A MTNR1B MYOT NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RHOA SELE SH2B3 SHBG SIGLEC10 SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	32 interactors: ARF1 CALM1 CNKSR2 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA HRAS LRPAP1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RAP1A RAP2A RAP2B RASSF5 REPS1 RGL2 RGL4 SMAD4 YBX3
Entrez ID		2316	5898
HPRD ID		02060	01549
Ensembl ID		ENSG00000196924	ENSG00000006451
Uniprot IDs		P21333 Q60FE5 Q6NXF2	P11233
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH	1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV
Enriched GO Terms of Interacting Partners?		Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Stress Regulation Of Phosphorus Metabolic Process Wound Healing Response To Wounding Regulation Of Signaling Positive Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Response To External Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Response To Abiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Tissue Development Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Multicellular Organismal Development System Development Cellular Response To Organic Substance Regulation Of Apoptotic Process Developmental Process	Exocytosis Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Membrane Organization Secretion By Cell Intracellular Signal Transduction Secretion Ras Protein Signal Transduction Establishment Of Protein Localization Protein Localization Vesicle Docking Protein Transport Membrane Docking Rap Protein Signal Transduction Establishment Of Localization In Cell Cellular Localization Vesicle Docking Involved In Exocytosis Positive Regulation Of Protein Autophosphorylation Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Transport Regulation Of Protein Autophosphorylation Organelle Organization Regulation Of Signal Transduction Golgi Vesicle Transport Exocyst Localization Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cellular Protein Complex Localization Blood Coagulation Cell Communication Positive Regulation Of Ras GTPase Activity Hemostasis Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of GTPase Activity Protein Complex Localization Cellular Response To Stimulus Regulation Of Cell Projection Organization Regulation Of GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Body Fluid Levels Wound Healing Golgi To Plasma Membrane Transport
Tagcloud ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Difference) ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Intersection) ?