FLNA and SIRPA

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		FLNA	SIRPA
Description		filamin A	signal regulatory protein alpha
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GO Annotations	Cellular Component	Podosome Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Growth Cone Cortical Cytoskeleton Myb Complex Cell Projection Neuronal Cell Body Dendritic Shaft Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Apical Dendrite Postsynapse Glutamatergic Synapse Glycoprotein Ib-IX-V Complex	Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Actin Binding Protein Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Protein Phosphatase Inhibitor Activity Protein Binding SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding
	Biological Process	Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Bundle Assembly Protein Localization To Cell Surface Megakaryocyte Development Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Establishment Of Protein Localization Protein Stabilization Release Of Sequestered Calcium Ion Into Cytosol Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Cell Adhesion Regulation Of Gene Expression Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Cell-cell Adhesion Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs		Artenimol
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 19820697 22139419 27863252 32888494) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		106 interacting genes: ADAMTSL4 ANKRD13C-DT APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CDK1 CEACAM1 CEBPA CFL1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HMGB2 HNRNPD HSPA6 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MTOR MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PDE4B PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 PTEN RAC1 RALA REL RFLNA RHOA RNF10 SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL XIAP YWHAG	60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM
Entrez ID		2316	140885
HPRD ID		02060	03912
Ensembl ID		ENSG00000196924	ENSG00000198053
Uniprot IDs		P21333 Q60FE5 Q6NXF2	P78324
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1 7SC4 7SFT 9LWX 9LXG	2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV 7KPG 7ST5 7YGG
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Migration Regulation Of Biological Quality Regulation Of Synaptic Transmission, Glutamatergic Focal Adhesion Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Cellular Response To Oxygen-containing Compound Regulation Of Developmental Process Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Regulation Of System Process Regulation Of Membrane Potential Glutamatergic Synapse Enzyme Binding Positive Regulation Of MAPK Cascade Plasma Membrane Response To Stress Regulation Of Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cell Junction Organization Positive Regulation Of Locomotion Actin Filament-based Process	Extracellular Exosome Focal Adhesion Supramolecular Fiber Organization ATP-dependent Protein Folding Chaperone Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Folding Chaperone Structural Constituent Of Skin Epidermis Cytoplasm Keratin Filament Nucleotide Binding Intermediate Filament Unfolded Protein Binding Structural Molecule Activity Cytoskeleton Organization Protein Folding Protein Folding In Endoplasmic Reticulum Non-membrane Spanning Protein Tyrosine Phosphatase Activity Maintenance Of Location Plasma Membrane Bounded Cell Projection Organization Organelle Organization Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Cadherin Binding T Cell Costimulation Protein Metabolic Process Protein Binding Platelet Formation Regulation Of Nitric Oxide Biosynthetic Process RNA Binding Response To Interleukin-12 Megakaryocyte Development Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Metabolic Process Heat Shock Protein Binding Regulation Of Nitric Oxide Metabolic Process Epithelial Cell Differentiation ATP Binding MHC Class II Protein Complex Binding Cell Projection Organization Sequestering Of Calcium Ion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Maintenance Of Location In Cell Protein Modification Process Glutamatergic Synapse Cytoskeleton
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