FLNA and MTOR

Number of citations of the paper that reports this interaction (PubMedID 26134617)
65

Data Source:
BioGRID (enzymatic study)

		FLNA	MTOR
Description		filamin A	mechanistic target of rapamycin kinase
Image
GO Annotations	Cellular Component	Podosome Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Growth Cone Cortical Cytoskeleton Myb Complex Cell Projection Neuronal Cell Body Dendritic Shaft Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Apical Dendrite Postsynapse Glutamatergic Synapse Glycoprotein Ib-IX-V Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane PML Body Dendrite Cytoplasmic Vesicle TORC1 Complex TORC2 Complex Phagocytic Vesicle Serine/threonine Protein Kinase Complex
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Actin Binding Protein Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Nucleotide Binding Inositol Hexakisphosphate Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Phosphoprotein Binding Protein Serine Kinase Activity
	Biological Process	Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Bundle Assembly Protein Localization To Cell Surface Megakaryocyte Development Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Establishment Of Protein Localization Protein Stabilization Release Of Sequestered Calcium Ion Into Cytosol Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Autophagosome Assembly Regulation Of Cell Growth Cytoplasmic Translation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Inflammatory Response DNA Damage Response Cytoskeleton Organization Lysosome Organization Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Size Cellular Response To Starvation Response To Heat Response To Virus Post-embryonic Development Positive Regulation Of Biosynthetic Process Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Macroautophagy Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Regulation Of Lipid Metabolic Process Neuronal Action Potential Cell Projection Organization Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Ruffle Organization Regulation Of Myelination Protein Destabilization Response To Nutrient Levels Cellular Response To Nutrient Levels Cellular Response To Nutrient TOR Signaling Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Starvation Multicellular Organism Growth TORC1 Signaling TORC2 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Amino Acid Anoikis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Glycolytic Process Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Behavioral Response To Pain Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Cardiac Muscle Tissue Development Protein Stabilization Voluntary Musculoskeletal Movement Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Cell Development Cardiac Muscle Cell Development Cardiac Muscle Contraction Cellular Response To Methionine Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Cellular Response To Stress Regulation Of Membrane Permeability Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Antibacterial Innate Immune Response Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of TORC2 Signaling Regulation Of Locomotor Rhythm Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Cytoplasmic Translational Initiation Regulation Of Lysosome Organization Negative Regulation Of Lysosome Organization Positive Regulation Of Pentose-phosphate Shunt Cellular Response To Leucine Starvation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Autophagosome Assembly
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Artenimol	Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus GSK-1059615 Fostamatinib Oleandrin
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	A body shape index ( 34021172) Beard thickness ( 26926045) Body mass index ( 25673413) Body mass index and type 2 diabetes (pairwise) ( 33619380) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		106 interacting genes: ADAMTSL4 ANKRD13C-DT APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CDK1 CEACAM1 CEBPA CFL1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HMGB2 HNRNPD HSPA6 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MTOR MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PDE4B PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 PTEN RAC1 RALA REL RFLNA RHOA RNF10 SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL XIAP YWHAG	61 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 FLNA GPHN GSK3B HRAS IRS1 MAF1 MAPKAP1 MLST8 NRAS PA2G4 PCNA PDPK1 PLD2 PLEKHM1 PPP2R2A PREX1 PRKAA1 PRKCA PRKN PRR5L RAB1A RHEB RHEBL1 RICTOR RPS6 RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 ULK1 UVRAG WIPI2 YWHAQ ZNRF2
Entrez ID		2316	2475
HPRD ID		02060	03134
Ensembl ID		ENSG00000196924	ENSG00000198793
Uniprot IDs		P21333 Q60FE5 Q6NXF2	A0A8V8TQ52 P42345
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1 7SC4 7SFT 9LWX 9LXG	1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2 6ZWM 6ZWO 7EPD 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ER6 8ER7 8ERA 8PPZ 8RCH 8RCK 8RCN 9F44 9F45
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Migration Regulation Of Biological Quality Regulation Of Synaptic Transmission, Glutamatergic Focal Adhesion Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Cellular Response To Oxygen-containing Compound Regulation Of Developmental Process Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Regulation Of System Process Regulation Of Membrane Potential Glutamatergic Synapse Enzyme Binding Positive Regulation Of MAPK Cascade Plasma Membrane Response To Stress Regulation Of Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cell Junction Organization Positive Regulation Of Locomotion Actin Filament-based Process	TOR Signaling Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling Regulation Of Autophagy Intracellular Signaling Cassette Regulation Of TOR Signaling TORC2 Signaling Autophagosome Assembly Autophagosome Organization Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Apoptotic Process Cellular Response To Nutrient Levels Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of TOR Signaling Regulation Of Signaling Regulation Of Cell Communication Vacuole Organization Cytoplasm Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Autophagy Regulation Of Translational Initiation Negative Regulation Of Translational Initiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Translation Positive Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Regulation Of Biological Quality Protein Kinase Binding Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC1 Signaling Response To Nutrient Levels Organelle Organization Positive Regulation Of TORC1 Signaling Positive Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Cell Growth Regulation Of Cellular Component Organization Negative Regulation Of Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?