FLNA and GP1BA

Number of citations of the paper that reports this interaction (PubMedID 18299448)
41

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		FLNA	GP1BA
Description		filamin A	glycoprotein Ib platelet subunit alpha
Image
GO Annotations	Cellular Component	Podosome Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Growth Cone Cortical Cytoskeleton Myb Complex Cell Projection Neuronal Cell Body Dendritic Shaft Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Apical Dendrite Postsynapse Glutamatergic Synapse Glycoprotein Ib-IX-V Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Actin Binding Protein Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity
	Biological Process	Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Bundle Assembly Protein Localization To Cell Surface Megakaryocyte Development Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Establishment Of Protein Localization Protein Stabilization Release Of Sequestered Calcium Ion Into Cytosol Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		Artenimol	Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia	Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Keratoconus ( 33649486) Mean platelet volume ( 27863252 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		106 interacting genes: ADAMTSL4 ANKRD13C-DT APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CDK1 CEACAM1 CEBPA CFL1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HMGB2 HNRNPD HSPA6 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MTOR MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PDE4B PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 PTEN RAC1 RALA REL RFLNA RHOA RNF10 SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL XIAP YWHAG	17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		2316	2811
HPRD ID		02060	01976
Ensembl ID		ENSG00000196924	ENSG00000185245
Uniprot IDs		P21333 Q60FE5 Q6NXF2	L7UYB8 P07359
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1 7SC4 7SFT 9LWX 9LXG	1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Migration Regulation Of Biological Quality Regulation Of Synaptic Transmission, Glutamatergic Focal Adhesion Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Cellular Response To Oxygen-containing Compound Regulation Of Developmental Process Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Regulation Of System Process Regulation Of Membrane Potential Glutamatergic Synapse Enzyme Binding Positive Regulation Of MAPK Cascade Plasma Membrane Response To Stress Regulation Of Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cell Junction Organization Positive Regulation Of Locomotion Actin Filament-based Process	Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process
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