FLNA and FLNB

Number of citations of the paper that reports this interaction (PMID 12393796)
26

Data Source:
HPRD (two hybrid, in vivo)

		FLNA	FLNB
Gene Name		filamin A, alpha	filamin B, beta
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cortical Cytoskeleton Myb Complex Neuronal Cell Body Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Apical Dendrite	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding Ral GTPase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Poly(A) RNA Binding SMAD Binding Rac GTPase Binding Actin Filament Binding	Actin Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Epithelial To Mesenchymal Transition Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation Platelet Activation Actin Cytoskeleton Reorganization Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Cilium Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Early Endosome To Late Endosome Transport Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Platelet Aggregation Mitotic Spindle Assembly	Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Skeletal Muscle Tissue Development Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Cell Differentiation
Pathways		Cell junction organization GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell-extracellular matrix interactions	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457)
Protein-Protein Interactions		82 interactors: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FAM101A FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MTNR1A MTNR1B MYOT NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RHOA SELE SH2B3 SHBG SIGLEC10 SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	17 interactors: ASB2 ATF7IP FBLIM1 FLNA GP1BA ITGB1 ITGB3 ITGB6 MLH1 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 SMURF2 TRIM55 TSHR
Entrez ID		2316	2317
HPRD ID		02060	04543
Ensembl ID		ENSG00000196924	ENSG00000136068
Uniprot IDs		P21333 Q60FE5 Q6NXF2	E7EN95 O75369
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH	2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L
Enriched GO Terms of Interacting Partners?		Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Stress Regulation Of Phosphorus Metabolic Process Wound Healing Response To Wounding Regulation Of Signaling Positive Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Response To External Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Response To Abiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Tissue Development Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Multicellular Organismal Development System Development Cellular Response To Organic Substance Regulation Of Apoptotic Process Developmental Process	Cell Activation Cell Adhesion Single Organismal Cell-cell Adhesion Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Viral Entry Into Host Cell Entry Into Host Cell Lymphocyte Activation Cell Junction Assembly Regulation Of Peptidyl-tyrosine Phosphorylation Single-organism Behavior Cell Development Leukocyte Activation Amyloid Precursor Protein Catabolic Process Regulation Of Cellular Process Response To Stimulus Neuron Development Cell Fate Specification Behavior Interaction With Host Embryonic Morphogenesis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Cell Surface Receptor Signaling Pathway Homotypic Cell-cell Adhesion Leukocyte Differentiation Neuron Differentiation Integrin-mediated Signaling Pathway Tissue Development Cell Projection Organization Immune System Development Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Signal Transduction Cell Differentiation Heterotypic Cell-cell Adhesion Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Stress Developmental Process Leukocyte Activation Involved In Immune Response B Cell Activation Blood Coagulation Cell-matrix Adhesion Hemostasis Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	actionable algorithms asf1 assuming candidates distinguishing driver genomes grm1 hcf1 hierarchically interpreting involve machinery modules neutral organized passenger pou2f1 precisely presents prkcz psnv psnvs snvs thousands uncovered unexpectedly ways
Tagcloud (Difference) ?		actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles	actionable algorithms asf1 assuming candidates distinguishing driver genomes grm1 hcf1 hierarchically interpreting involve machinery modules neutral organized passenger pou2f1 precisely presents prkcz psnv psnvs snvs thousands uncovered unexpectedly ways
Tagcloud (Intersection) ?