FLNA and CASR

Number of citations of the paper that reports this interaction (PubMedID 11390379)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		FLNA	CASR
Description		filamin A	calcium sensing receptor
Image
GO Annotations	Cellular Component	Podosome Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Growth Cone Cortical Cytoskeleton Myb Complex Cell Projection Neuronal Cell Body Dendritic Shaft Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Apical Dendrite Postsynapse Glutamatergic Synapse Glycoprotein Ib-IX-V Complex	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Presynaptic Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Actin Binding Protein Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Bundle Assembly Protein Localization To Cell Surface Megakaryocyte Development Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Establishment Of Protein Localization Protein Stabilization Release Of Sequestered Calcium Ion Into Cytosol Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Ossification Response To Ischemia Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Response To Metal Ion Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Response To Calcium Ion Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Regulation Of Presynaptic Membrane Potential Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Artenimol	Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia	Bartter syndrome
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	Calcium levels ( 20661308 20705733 24068962 29403010 25886283 25972035) Cardiac Troponin-T levels ( 23247143) Chronic widespread musculoskeletal pain ( 33331911) Clinical laboratory measurements ( 27897004) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) QT interval ( 29874175) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		106 interacting genes: ADAMTSL4 ANKRD13C-DT APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CDK1 CEACAM1 CEBPA CFL1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HMGB2 HNRNPD HSPA6 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MTOR MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PDE4B PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 PTEN RAC1 RALA REL RFLNA RHOA RNF10 SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL XIAP YWHAG	11 interacting genes: FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL
Entrez ID		2316	846
HPRD ID		02060	03122
Ensembl ID		ENSG00000196924	ENSG00000036828
Uniprot IDs		P21333 Q60FE5 Q6NXF2	P41180
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1 7SC4 7SFT 9LWX 9LXG	5FBH 5FBK 5K5S 5K5T 7DTT 7DTU 7DTV 7DTW 7E6T 7E6U 7M3E 7M3F 7M3G 7M3J 7SIL 7SIM 7SIN 8SZF 8SZG 8SZH 8SZI 8WPG 8WPU 9ASB 9AVG 9AVL 9AXF 9AYF 9C1P 9C2F 9J7I
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Migration Regulation Of Biological Quality Regulation Of Synaptic Transmission, Glutamatergic Focal Adhesion Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Cellular Response To Oxygen-containing Compound Regulation Of Developmental Process Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Regulation Of System Process Regulation Of Membrane Potential Glutamatergic Synapse Enzyme Binding Positive Regulation Of MAPK Cascade Plasma Membrane Response To Stress Regulation Of Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cell Junction Organization Positive Regulation Of Locomotion Actin Filament-based Process	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Secretion By Cell Regulation Of Secretion Protein Kinase C Signaling Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Exocytosis Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Synaptic Signaling Via Neuropeptide Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Transcription Regulator Activator Activity Mitotic Nuclear Membrane Disassembly Regulation Of Programmed Cell Death Positive Regulation Of Insulin Secretion Regulation Of Protein Secretion Regulation Of Neural Precursor Cell Proliferation Regulation Of Signal Transduction Regulation Of Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Regulation Of Cell Population Proliferation Positive Regulation Of Peptide Secretion Regulation Of Blood Vessel Endothelial Cell Migration Calyx Of Held Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Hypoxia Glandular Epithelial Cell Differentiation Cellular Response To Decreased Oxygen Levels Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Enzyme Binding Plasma Membrane Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Biomineral Tissue Development Presynaptic Cytosol Cellular Response To Oxygen Levels
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