RAG1 and H2AC20

Number of citations of the paper that reports this interaction (PubMedID 20122409)
0

Data Source:
BioGRID (far western blotting)

		RAG1	H2AC20
Description		recombination activating 1	H2A clustered histone 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Histone Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endonuclease Activity	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Chromatin Organization Immune Response Visual Learning B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Regulation Of Behavioral Fear Response	Heterochromatin Formation
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Rheumatoid arthritis ( 24390342)
Interacting Genes		19 interacting genes: APP CDC34 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4C16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 TP53 UBC UBE2C UBE2D1 UBE2D2 UBE2H	72 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CEBPA CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBE2H UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8
Entrez ID		5896	8338
HPRD ID		01556	09107
Ensembl ID		ENSG00000166349	ENSG00000184260
Uniprot IDs		P15918	Q16777
PDB IDs			6Y5E 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8SPS 8SPU 8SYP
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Ubiquitin Conjugating Enzyme Activity V(D)J Recombination Structural Constituent Of Chromatin Protein Heterodimerization Activity Protein K48-linked Ubiquitination Somatic Cell DNA Recombination Nucleosome Assembly RAGE Receptor Binding Nucleus Nucleosome Nucleoplasm Nucleosome Organization Molecular Function Activator Activity Protein-DNA Complex Assembly Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Chemoattractant Activity Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex Assembly Proteolysis Involved In Protein Catabolic Process Chromosome Supercoiled DNA Binding B Cell Lineage Commitment Protein Modification By Small Protein Conjugation Positive Chemotaxis Epigenetic Regulation Of Gene Expression Protein Polyubiquitination DNA Binding DNA Metabolic Process DNA Geometric Change Protein-containing Complex Cell Activation Involved In Immune Response Protein-containing Complex Organization DNA Topological Change NLS-dependent Protein Nuclear Import Complex Regulation Of Carbohydrate Catabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Chromosome Organization Post-translational Protein Modification Catabolic Process Negative Regulation Of Neuroblast Proliferation Regulation Of Cell Differentiation Regulation Of MiRNA Transcription Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle	Chromatin Organization Chromatin Remodeling Nucleus Histone Binding Nucleoplasm Epigenetic Regulation Of Gene Expression Chromatin Binding Chromosome Protein Modification Process Macromolecule Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Gene Expression Histone H4 Acetyltransferase Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone H2A Deubiquitinase Activity Protein Deubiquitination Regulation Of DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity DNA Damage Response Protein Modification By Small Protein Removal Negative Regulation Of Biosynthetic Process Transferase Activity Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cysteine-type Peptidase Activity Protein-containing Complex Positive Regulation Of DNA-templated Transcription
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