RAG1 and UBE2H

Number of citations of the paper that reports this interaction (PMID 21256161)
5

Data Source:
BioGRID (pull down)

		RAG1	UBE2H
Gene Name		recombination activating gene 1	ubiquitin-conjugating enzyme E2H
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytoplasm
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: HIST1H3A HIST2H2AC HIST2H2BE HIST3H3 HIST4H4 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBE2D2 UBE2H VPRBP	57 interactors: BRAP BYSL CBLC CD99 DTX3 DTX3L DZIP3 EPS15 HDAC6 HIST2H2AA3 JADE1 LRSAM1 MARCH1 MARCH10 MARCH2 MARCH4 MARCH8 MKRN3 NEURL1 NHLRC1 POLL POLM RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 UBA1 UBASH3B UBOX5 UBR2
Entrez ID		5896	7328
HPRD ID		01556	03052
Ensembl ID		ENSG00000166349	ENSG00000186591
Uniprot IDs		P15918	A4D1L5 P62256
PDB IDs			2Z5D
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process V(D)J Recombination Chromosome Organization Chromatin Organization Apoptotic DNA Fragmentation DNA Conformation Change Nucleosome Assembly Apoptotic Nuclear Changes Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Base-excision Repair, DNA Ligation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis DNA Recombination Execution Phase Of Apoptosis DNA Replication-dependent Nucleosome Assembly Chromatin Modification DNA Ligation Involved In DNA Repair DNA Catabolic Process, Endonucleolytic DNA Methylation On Cytosine DNA Ligation Chromatin Silencing At RDNA Regulation Of Megakaryocyte Differentiation DNA Catabolic Process NLS-bearing Protein Import Into Nucleus Cellular Macromolecule Catabolic Process Organelle Organization Positive Chemotaxis Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Regulation Of Hematopoietic Progenitor Cell Differentiation Chromatin Silencing DNA Topological Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Protein K48-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Immune System Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Nitrogen Compound Metabolic Process Immune System Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Protein Catabolic Process Histone Monoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Regulation Of Viral Entry Into Host Cell Cellular Macromolecule Catabolic Process Cellular Process Negative Regulation Of Protein Metabolic Process Histone Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Viral Process Regulation Of ERBB Signaling Pathway Protein Trimerization Aggresome Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K6-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromatin Modification Negative Regulation Of Cellular Protein Metabolic Process Proteolysis Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Negative Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated finger hetero homo homology hybrid interacting intrinsic necrosis oligomerization possess possesses prominent recombination segment substantial terminus traf traf1 traf2 utilized	0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Difference) ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated finger hetero homo homology hybrid interacting intrinsic necrosis oligomerization possess possesses prominent recombination segment substantial terminus traf traf1 traf2 utilized	0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Intersection) ?