RAG1 and HMGB2

Number of citations of the paper that reports this interaction (PMID 10490593)
42

Data Source:
HPRD (in vitro)

		RAG1	HMGB2
Gene Name		recombination activating gene 1	high mobility group box 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Poly(A) RNA Binding RAGE Receptor Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Positive Regulation Of Endothelial Cell Proliferation DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity V(D)J Recombination Positive Regulation Of DNA Binding Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: HIST1H3A HIST2H2AC HIST2H2BE HIST3H3 HIST4H4 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBE2D2 UBE2H VPRBP	20 interactors: APEX1 APP AR CHAF1A CREBBP CSNK1A1 GZMA GZMK HMGA1 NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SET TP53
Entrez ID		5896	3148
HPRD ID		01556	01229
Ensembl ID		ENSG00000166349
Uniprot IDs		P15918	P26583
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process V(D)J Recombination Chromosome Organization Chromatin Organization Apoptotic DNA Fragmentation DNA Conformation Change Nucleosome Assembly Apoptotic Nuclear Changes Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Base-excision Repair, DNA Ligation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis DNA Recombination Execution Phase Of Apoptosis DNA Replication-dependent Nucleosome Assembly Chromatin Modification DNA Ligation Involved In DNA Repair DNA Catabolic Process, Endonucleolytic DNA Methylation On Cytosine DNA Ligation Chromatin Silencing At RDNA Regulation Of Megakaryocyte Differentiation DNA Catabolic Process NLS-bearing Protein Import Into Nucleus Cellular Macromolecule Catabolic Process Organelle Organization Positive Chemotaxis Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Regulation Of Hematopoietic Progenitor Cell Differentiation Chromatin Silencing DNA Topological Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Protein K48-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Immune System Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Nitrogen Compound Metabolic Process Immune System Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Chromosome Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Chromatin Organization Cellular Metabolic Process Developmental Process Lymphocyte Differentiation B Cell Differentiation Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Assembly Leukocyte Differentiation T Cell Differentiation Chromatin Assembly Or Disassembly B Cell Activation Positive Regulation Of Cell Aging Transcription Initiation From RNA Polymerase II Promoter B Cell Lineage Commitment Cell Activation Multicellular Organismal Development DNA Metabolic Process DNA Packaging Lymphocyte Activation Intracellular Receptor Signaling Pathway
Tagcloud ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated finger hetero homo homology hybrid interacting intrinsic necrosis oligomerization possess possesses prominent recombination segment substantial terminus traf traf1 traf2 utilized	advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Difference) ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated finger hetero homo homology hybrid interacting intrinsic necrosis oligomerization possess possesses prominent recombination segment substantial terminus traf traf1 traf2 utilized	advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Intersection) ?