RAG1 and HIST3H3

Number of citations of the paper that reports this interaction (PMID 20122409)
6

Data Source:
BioGRID (affinity chromatography technology, pull down, far western blotting, enzymatic study)

		RAG1	HIST3H3
Gene Name		recombination activating gene 1	histone cluster 3, H3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis	Telomere Maintenance
Pathways			DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: HIST1H3A HIST2H2AC HIST2H2BE HIST3H3 HIST4H4 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBE2D2 UBE2H VPRBP	183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516
Entrez ID		5896	8290
HPRD ID		01556	04156
Ensembl ID		ENSG00000166349	ENSG00000168148
Uniprot IDs		P15918	Q16695
PDB IDs			2V1D 2YBP 2YBS 3A6N 3T6R
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process V(D)J Recombination Chromosome Organization Chromatin Organization Apoptotic DNA Fragmentation DNA Conformation Change Nucleosome Assembly Apoptotic Nuclear Changes Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Base-excision Repair, DNA Ligation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis DNA Recombination Execution Phase Of Apoptosis DNA Replication-dependent Nucleosome Assembly Chromatin Modification DNA Ligation Involved In DNA Repair DNA Catabolic Process, Endonucleolytic DNA Methylation On Cytosine DNA Ligation Chromatin Silencing At RDNA Regulation Of Megakaryocyte Differentiation DNA Catabolic Process NLS-bearing Protein Import Into Nucleus Cellular Macromolecule Catabolic Process Organelle Organization Positive Chemotaxis Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Regulation Of Hematopoietic Progenitor Cell Differentiation Chromatin Silencing DNA Topological Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Protein K48-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Immune System Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Nitrogen Compound Metabolic Process Immune System Process	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression
Tagcloud ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated finger hetero homo homology hybrid interacting intrinsic necrosis oligomerization possess possesses prominent recombination segment substantial terminus traf traf1 traf2 utilized	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated finger hetero homo homology hybrid interacting intrinsic necrosis oligomerization possess possesses prominent recombination segment substantial terminus traf traf1 traf2 utilized	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?