RAG1 and RAG2

Number of citations of the paper that reports this interaction (PMID 9036966)
14

Data Source:
HPRD (in vitro, in vivo)

		RAG1	RAG2
Gene Name		recombination activating gene 1	recombination activating gene 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	DNA Binding Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Methylated Histone Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis	B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment Chromatin Modification B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination Positive Regulation Of Organ Growth
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: HIST1H3A HIST2H2AC HIST2H2BE HIST3H3 HIST4H4 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBE2D2 UBE2H VPRBP	3 interactors: IPO5 RAG1 SKP2
Entrez ID		5896	5897
HPRD ID		01556	08913
Ensembl ID		ENSG00000166349	ENSG00000175097
Uniprot IDs		P15918	P55895
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process V(D)J Recombination Chromosome Organization Chromatin Organization Apoptotic DNA Fragmentation DNA Conformation Change Nucleosome Assembly Apoptotic Nuclear Changes Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Base-excision Repair, DNA Ligation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis DNA Recombination Execution Phase Of Apoptosis DNA Replication-dependent Nucleosome Assembly Chromatin Modification DNA Ligation Involved In DNA Repair DNA Catabolic Process, Endonucleolytic DNA Methylation On Cytosine DNA Ligation Chromatin Silencing At RDNA Regulation Of Megakaryocyte Differentiation DNA Catabolic Process NLS-bearing Protein Import Into Nucleus Cellular Macromolecule Catabolic Process Organelle Organization Positive Chemotaxis Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Regulation Of Hematopoietic Progenitor Cell Differentiation Chromatin Silencing DNA Topological Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Protein K48-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Immune System Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Nitrogen Compound Metabolic Process Immune System Process	Cellular Response To Cell-matrix Adhesion Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Pre-B Cell Allelic Exclusion Ribosomal Protein Import Into Nucleus Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Pre-B Cell Differentiation NLS-bearing Protein Import Into Nucleus Immature B Cell Differentiation Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Thymocyte Apoptotic Process Histone Monoubiquitination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of T Cell Apoptotic Process V(D)J Recombination Histone Ubiquitination T Cell Homeostasis
Tagcloud ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated finger hetero homo homology hybrid interacting intrinsic necrosis oligomerization possess possesses prominent recombination segment substantial terminus traf traf1 traf2 utilized	abrogated advance allowing c325y capable carrying catalyzing cleavage collectively core cysteine doi facilitates finger interacting j january mono online publication rag1 recombination residue restrains ring triggers ubiquitylated ubiquitylation un
Tagcloud (Difference) ?		associate associating cd40 cdnas clone coil coiled cytoplasmic designated hetero homo homology hybrid intrinsic necrosis oligomerization possess possesses prominent segment substantial terminus traf traf1 traf2 utilized	abrogated advance allowing c325y capable carrying catalyzing cleavage collectively core cysteine doi facilitates j january mono online publication residue restrains ring triggers ubiquitylated ubiquitylation un
Tagcloud (Intersection) ?		finger interacting rag1 recombination