MYL1 and IQGAP1

Number of citations of the paper that reports this interaction (PubMedID 18587628)
0

Data Source:
BioGRID (unspecified method)

		MYL1	IQGAP1
Description		myosin light chain 1	IQ motif containing GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Contractile Muscle Fiber	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Cortical Actin Cytoskeleton Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Exosome Plasma Membrane Bounded Cell Projection Ribonucleoprotein Complex
	Molecular Function	Calcium Ion Binding Structural Constituent Of Muscle	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Molecular Adaptor Activity
	Biological Process	Muscle Contraction Muscle Filament Sliding	MAPK Cascade Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Migration Cell Migration Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway Caveola Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Podocyte Development Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Neuron Projection Extension
Pathways		Striated Muscle Contraction	Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Artenimol
Diseases
GWAS		Serum metabolite levels ( 23093944)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Chronic postoperative pain ( 31903573) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)
Interacting Genes		7 interacting genes: ACTA1 ACTA2 ANKRD1 APP EPB41 IQGAP1 UBC	45 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CDK1 CDK2 CEBPA CLIC5 CLIP1 CREBBP CTNNB1 CYBB DSCAM DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 LCOR MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 NRIP1 NUMB OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP
Entrez ID		4632	8826
HPRD ID		01180	04541
Ensembl ID		ENSG00000168530	ENSG00000140575
Uniprot IDs		P05976	A0A0J9YXZ5 P46940
PDB IDs			1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Mesenchyme Migration Cell Body Actomyosin Structure Organization Positive Regulation Of MAPK Cascade Supramolecular Fiber Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cytosol Regulation Of MAPK Cascade Muscle System Process Actin Cytoskeleton Regulation Of ERK1 And ERK2 Cascade Protein-containing Complex Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cell Development Cellular Developmental Process Positive Regulation Of Signal Transduction Positive Regulation Of Hepatic Stellate Cell Contraction Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Developmental Growth Filopodium Actin Filament Stress Fiber Response To Interleukin-1 Actin Filament-based Process Cytoplasm Structural Constituent Of Cytoskeleton Positive Regulation Of Hepatic Stellate Cell Migration Regulation Of Intracellular Signal Transduction Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization Skeletal Myofibril Assembly Extracellular Exosome Juxtaglomerular Apparatus Development PTB Domain Binding	Intracellular Signaling Cassette Cadherin Binding Focal Adhesion Positive Regulation Of Protein Localization Developmental Process Lamellipodium Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Organelle Organization Cellular Developmental Process Centrosome Intracellular Signal Transduction Glutamatergic Synapse Cell Development Neuron Fate Determination Cell Projection Cytoskeleton Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Protein Localization Cell Junction Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Cellular Localization Actin Cytoskeleton Adherens Junction Cytoplasm Adherens Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Phosphorylation Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Locomotion Regulation Of Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cytosol Cyclin-dependent Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Locomotion
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