MYL1 and ANKRD1

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		MYL1	ANKRD1
Name		myosin light chain 1	ankyrin repeat domain 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Contractile Muscle Fiber	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Myofibril I Band Protein-containing Complex
	Molecular Function	Calcium Ion Binding Structural Constituent Of Muscle	P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding
	Biological Process	Muscle Contraction Muscle Filament Sliding	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of DNA Biosynthetic Process
Pathways		Striated Muscle Contraction	PPARA activates gene expression
GWAS		Serum metabolite levels ( 23093944 )	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Intraocular pressure ( 29617998 ) Refractive error ( 32231278 )
Novel Interactors		1 novel interactors: CFLAR	None recorded
Interacting Genes		7 interacting genes: ACTA1 ACTA2 ANKRD1 APP EPB41 IQGAP1 UBC	23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446
Entrez ID		4632	27063
HPRD ID		01180	10647
Ensembl ID		ENSG00000168530	ENSG00000148677
Uniprot IDs		P05976	A0A384NYH5 Q15327
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cellular Response To Growth Factor Stimulus Response To Growth Factor Mesenchyme Migration Cell Body Actomyosin Structure Organization Positive Regulation Of MAPK Cascade Supramolecular Fiber Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cytosol Regulation Of MAPK Cascade Muscle System Process Actin Cytoskeleton Regulation Of ERK1 And ERK2 Cascade Protein-containing Complex Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cell Development Cellular Developmental Process Positive Regulation Of Signal Transduction Positive Regulation Of Hepatic Stellate Cell Contraction Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Developmental Growth Filopodium Actin Filament Stress Fiber Response To Interleukin-1 Actin Filament-based Process Cytoplasm Structural Constituent Of Cytoskeleton Positive Regulation Of Hepatic Stellate Cell Migration Regulation Of Intracellular Signal Transduction Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization Skeletal Myofibril Assembly Extracellular Exosome Juxtaglomerular Apparatus Development PTB Domain Binding	Z Disc M Band Sarcomere Organization Structural Constituent Of Muscle Muscle Contraction Actin Filament-based Process Actomyosin Structure Organization Muscle System Process Microtubule Actin Cytoskeleton Organization Calcium Ion Binding Titin Binding Contractile Muscle Fiber Muscle Filament Sliding Muscle Alpha-actinin Binding Cytoskeleton Organization Actin-myosin Filament Sliding Microtubule Plus-end Binding Negative Regulation Of Phagocytosis Myosin Filament Microtubule Plus-end I Band Calcium Ion Sequestering Activity Actin-mediated Cell Contraction Monocyte Activation Involved In Immune Response Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity Beta-tubulin Binding Cardiac Muscle Contraction Structural Molecule Activity H Zone Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Limb Development Myofibril Sarcomere Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Condensed Nuclear Chromosome Sarcomerogenesis Bronchus Morphogenesis Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Positive Regulation Of Macropinocytosis N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation