EP400 and ALAS1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EP400	ALAS1
Gene Name		E1A binding protein p400	5-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Swr1 Complex Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	DNA Binding Chromatin Binding Helicase Activity ATP Binding	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Chromatin Organization Histone H4 Acetylation Histone H2A Acetylation	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		Chromatin modifying enzymes Formation of Senescence-Associated Heterochromatin Foci (SAHF) DNA Damage/Telomere Stress Induced Senescence Chromatin organization Cellular Senescence HATs acetylate histones	PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Glycine
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		4 interactors: ALAS1 MYC TBC1D4 TRRAP	40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		57634	211
HPRD ID		09378	00505
Ensembl ID		ENSG00000183495	ENSG00000023330
Uniprot IDs		Q96L91	P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Fibroblast Apoptotic Process	Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity
Tagcloud ?		arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating	adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?		arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating	adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?