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ARFGAP1 and GRN
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid)
ARFGAP1
GRN
Description
ARF GTPase activating protein 1
granulin precursor
Image
GO Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Golgi Apparatus
Cytosol
Synapse
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Vesicle
Azurophil Granule Lumen
Extracellular Exosome
Cerebellar Climbing Fiber To Purkinje Cell Synapse
Molecular Function
GTPase Activator Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Protein-folding Chaperone Binding
Biological Process
Protein Transport
Vesicle-mediated Transport
Regulation Of Endocytosis
Regulation Of ARF Protein Signal Transduction
Trophectodermal Cell Proliferation
Blastocyst Hatching
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Embryo Implantation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Locomotory Exploration Behavior
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
Positive Regulation Of Axon Regeneration
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Regulation Of Developmental Process
Protein Stabilization
Positive Regulation Of Cellular Component Organization
Establishment Of Localization In Cell
Retina Development In Camera-type Eye
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Maintenance Of Synapse Structure
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Trophectodermal Cell Proliferation
Lysosomal Protein Catabolic Process
Positive Regulation Of Aspartic-type Peptidase Activity
Regulation Of Lysosome Organization
Positive Regulation Of Lysosome Organization
Pathways
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Clathrin-mediated endocytosis
Neutrophil degranulation
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Mild age-related type 2 diabetes (
34737425
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
39 interacting genes:
AGTR1
APOB
APOC3
APOE
APP
ARF1
ASB10
COPA
COPS5
CRYAA
CSNK1D
CYTH2
FOS
GABARAPL1
GABARAPL2
GRN
HRAS
KDELR1
KRTAP10-9
KRTAP3-2
KRTAP9-2
LRRK2
MAP1LC3B
MED27
PRKACB
RAB23
RABGAP1L
RASIP1
REEP5
RFC3
RGS2
RPL11
SLC25A21-AS1
SLC6A1
SMN1
SNCA
TK1
TMED2
TRIM23
88 interacting genes:
ALG13
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT31
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1B
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
LCE5A
MBD1
MEOX2
NEDD8
NLK
NUFIP2
OTX1
P4HB
PCM1
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SHANK3
SLC13A1
SLPI
SMAD9
SMCP
SNRNP48
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
Entrez ID
55738
2896
HPRD ID
06443
00733
Ensembl ID
ENSG00000101199
ENSG00000030582
Uniprot IDs
Q53F62
Q8N6T3
P28799
PDB IDs
3DWD
3O47
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
8T8R
8T8S
Enriched GO Terms of Interacting Partners
?
Intermediate-density Lipoprotein Particle
Protein-containing Complex Organization
Phospholipid Binding
Vesicle-mediated Transport
Very-low-density Lipoprotein Particle
Golgi Apparatus
Plasma Lipoprotein Particle Assembly
Protein-lipid Complex Assembly
Protein-containing Complex Assembly
Lipoprotein Metabolic Process
Plasma Lipoprotein Particle Remodeling
Cellular Response To Nitrogen Starvation
Protein-containing Complex Remodeling
Cellular Component Assembly
Regulation Of Proteolysis
Cytoplasmic Vesicle
Beta-tubulin Binding
Vacuole Organization
Chylomicron
Phosphatidylethanolamine Binding
Low-density Lipoprotein Particle
Chylomicron Remnant
Negative Regulation Of Transport
Locomotory Exploration Behavior
Lipoprotein Particle
Low-density Lipoprotein Particle Remodeling
COPI-coated Vesicle Membrane
Endocytosis
Regulation Of Small Molecule Metabolic Process
Regulation Of Neuronal Synaptic Plasticity
Import Into Cell
Cytosol
Golgi Membrane
Growth Cone
Establishment Of Protein Localization
Regulation Of Protein Catabolic Process
Protein Transport
Establishment Of Localization In Cell
Cellular Response To Nutrient Levels
Low-density Lipoprotein Particle Receptor Binding
Regulation Of Long-term Neuronal Synaptic Plasticity
Astrocyte Activation Involved In Immune Response
Plasma Lipoprotein Particle Clearance
Autophagosome
Neutral Lipid Metabolic Process
Cholesterol Efflux
Microglial Cell Activation
Positive Regulation Of Inflammatory Response
Chylomicron Remnant Clearance
Triglyceride-rich Lipoprotein Particle Clearance
Keratinization
Intermediate Filament
Epidermis Development
Keratin Filament
Protein Binding
Tissue Development
P-TEFb Complex
Nuclear Matrix
Identical Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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