ARFGAP1 and CYTH2

Number of citations of the paper that reports this interaction (PMID 9476900)
35

Data Source:
HPRD (in vitro)

		ARFGAP1	CYTH2
Gene Name		ADP-ribosylation factor GTPase activating protein 1	cytohesin 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Golgi-associated Vesicle Membrane Synapse	Cytoplasm Trans-Golgi Network Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To ER Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport Endoplasmic Reticulum Unfolded Protein Response Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process COPI Coating Of Golgi Vesicle Membrane Organization	Endocytosis Vesicle-mediated Transport Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity
Pathways		IRE1alpha activates chaperones COPI Mediated Transport XBP1(S) activates chaperone genes Golgi to ER Retrograde Transport Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	21 interactors: ADORA2A APC ARF1 ARF6 ARFGAP1 ARRB1 ARRB2 ATP6V0A2 CCDC120 CUX1 CYTIP DYT10 GNAQ IPCEF1 ITGB2 MAPK6 PNPLA2 PRKCA PRKCB PRKCG TRIM23
Entrez ID		55738	9266
HPRD ID		06443	03925
Ensembl ID		ENSG00000101199	ENSG00000105443
Uniprot IDs		B7Z3U0 B7Z8H8 E7EV62 Q53F62 Q8N6T3	Q99418
PDB IDs		3DWD 3O47	1PBV 1R8M 1R8Q 1R8S 1S9D
Enriched GO Terms of Interacting Partners?		Triglyceride Catabolic Process Acylglycerol Catabolic Process Vesicle-mediated Transport COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Response To Extracellular Stimulus Protein-lipid Complex Assembly Protein Transport Establishment Of Protein Localization Plasma Lipoprotein Particle Remodeling Cholesterol Efflux Cellular Component Assembly Triglyceride Metabolic Process Protein Localization Vesicle Targeting, To, From Or Within Golgi Neutral Lipid Metabolic Process Response To Nutrient Levels Cholesterol Metabolic Process Plasma Lipoprotein Particle Clearance Sterol Metabolic Process Localization Within Membrane Vesicle Targeting Autophagic Vacuole Assembly Transport Cellular Lipid Catabolic Process Autophagy Regulation Of Catalytic Activity Response To Light Stimulus Macroautophagy Triglyceride Mobilization Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Membrane Organization Regulation Of Plasma Lipoprotein Particle Levels Low-density Lipoprotein Particle Remodeling Cholesterol Transport Sterol Transport Glycerolipid Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Signaling Phospholipid Efflux Negative Regulation Of Hydrolase Activity Endocytosis Regulation Of Protein Processing Regulation Of Proteolysis Phototransduction, Visible Light Cholesterol Homeostasis Cellular Response To Extracellular Stimulus Sterol Homeostasis	Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signal Transduction Apoptotic Process Programmed Cell Death Signaling Histone H3-T6 Phosphorylation Cell Death Death Cell Communication Positive Regulation Of Metabolic Process Regulation Of Receptor Internalization Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Activation Of Phospholipase C Activity Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of Phospholipase C Activity Regulation Of Endocytosis Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase Activity Regulation Of Catalytic Activity Membrane Organization COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of Phosphorylation Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity G-protein Coupled Receptor Internalization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Lipase Activity Enzyme Linked Receptor Protein Signaling Pathway Golgi Vesicle Transport Protein Localization Golgi Vesicle Budding Positive Regulation Of Cellular Metabolic Process Protein Transport Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Glucose Transport Vesicle-mediated Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Establishment Of Protein Localization
Tagcloud ?		accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Difference) ?		accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Intersection) ?