ARFGAP1 and TMED2

Number of citations of the paper that reports this interaction (PMID 11703931)
36

Data Source:
HPRD (in vitro)

		ARFGAP1	TMED2
Gene Name		ADP-ribosylation factor GTPase activating protein 1	transmembrane emp24 domain trafficking protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Golgi-associated Vesicle Membrane Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Integral Component Of Membrane COPI-coated Vesicle COPI-coated Vesicle Membrane Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Zymogen Granule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To ER Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport Endoplasmic Reticulum Unfolded Protein Response Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process COPI Coating Of Golgi Vesicle Membrane Organization	Maternal Placenta Development Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Golgi Organization Negative Regulation Of GTPase Activity Cargo Loading Into Vesicle COPI Coating Of Golgi Vesicle COPII Vesicle Coating Embryonic Morphogenesis Protein Targeting To Plasma Membrane
Pathways		IRE1alpha activates chaperones COPI Mediated Transport XBP1(S) activates chaperone genes Golgi to ER Retrograde Transport Unfolded Protein Response (UPR)	Pre-NOTCH Processing in Golgi Signaling by NOTCH Pre-NOTCH Expression and Processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	9 interactors: AKT2 ARF1 ARFGAP1 COPA GOLGA2 GORASP1 GORASP2 SEC23B TMED10
Entrez ID		55738	10959
HPRD ID		06443	17984
Ensembl ID		ENSG00000101199	ENSG00000086598
Uniprot IDs		B7Z3U0 B7Z8H8 E7EV62 Q53F62 Q8N6T3	Q15363 Q6FHT8
PDB IDs		3DWD 3O47
Enriched GO Terms of Interacting Partners?		Triglyceride Catabolic Process Acylglycerol Catabolic Process Vesicle-mediated Transport COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Response To Extracellular Stimulus Protein-lipid Complex Assembly Protein Transport Establishment Of Protein Localization Plasma Lipoprotein Particle Remodeling Cholesterol Efflux Cellular Component Assembly Triglyceride Metabolic Process Protein Localization Vesicle Targeting, To, From Or Within Golgi Neutral Lipid Metabolic Process Response To Nutrient Levels Cholesterol Metabolic Process Plasma Lipoprotein Particle Clearance Sterol Metabolic Process Localization Within Membrane Vesicle Targeting Autophagic Vacuole Assembly Transport Cellular Lipid Catabolic Process Autophagy Regulation Of Catalytic Activity Response To Light Stimulus Macroautophagy Triglyceride Mobilization Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Membrane Organization Regulation Of Plasma Lipoprotein Particle Levels Low-density Lipoprotein Particle Remodeling Cholesterol Transport Sterol Transport Glycerolipid Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Signaling Phospholipid Efflux Negative Regulation Of Hydrolase Activity Endocytosis Regulation Of Protein Processing Regulation Of Proteolysis Phototransduction, Visible Light Cholesterol Homeostasis Cellular Response To Extracellular Stimulus Sterol Homeostasis	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Localization Within Membrane Vesicle Targeting Membrane Budding Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Establishment Of Vesicle Localization Protein Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Intracellular Transport Membrane Organization Intracellular Protein Transport Organelle Localization Establishment Of Localization In Cell Cellular Protein Localization Cellular Localization Vesicle-mediated Transport Organelle Organization Golgi Organization Transport Endomembrane System Organization ER To Golgi Vesicle-mediated Transport Secretion Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Import In Response To Insulin Stimulus Mitotic Cell Cycle Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Pancreatic Juice Secretion Cargo Loading Into Vesicle Negative Regulation Of Dendrite Morphogenesis Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Vesicle Fusion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Negative Regulation Of Dendrite Development Long Term Synaptic Depression Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Cellular Copper Ion Homeostasis COPII Vesicle Coating
Tagcloud ?		accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic	androgens benzoate biphasic chosen clarified constantly converted defeminization defeminized dimorphism eb encording estradiol hcrt hypothalamus klc1 masculinization masculinized nedd4 neuroprotection orexin peaked perinatal prostaglandin ptgds rodents semiquantitative seventy testicular
Tagcloud (Difference) ?		accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic	androgens benzoate biphasic chosen clarified constantly converted defeminization defeminized dimorphism eb encording estradiol hcrt hypothalamus klc1 masculinization masculinized nedd4 neuroprotection orexin peaked perinatal prostaglandin ptgds rodents semiquantitative seventy testicular
Tagcloud (Intersection) ?