ARFGAP1 and REEP5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ARFGAP1	REEP5
Gene Name		ADP-ribosylation factor GTPase activating protein 1	receptor accessory protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Golgi-associated Vesicle Membrane Synapse	Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Molecular_function Protein Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To ER Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport Endoplasmic Reticulum Unfolded Protein Response Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process COPI Coating Of Golgi Vesicle Membrane Organization	Biological_process
Pathways		IRE1alpha activates chaperones COPI Mediated Transport XBP1(S) activates chaperone genes Golgi to ER Retrograde Transport Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		31 interactors: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	7 interactors: ARFGAP1 GTF2H1 NUDT3 RAB5B RABAC1 RGS2 VKORC1
Entrez ID		55738	7905
HPRD ID		06443	15918
Ensembl ID		ENSG00000101199	ENSG00000129625
Uniprot IDs		B7Z3U0 B7Z8H8 E7EV62 Q53F62 Q8N6T3	B7Z681 Q00765
PDB IDs		3DWD 3O47
Enriched GO Terms of Interacting Partners?		Triglyceride Catabolic Process Acylglycerol Catabolic Process Vesicle-mediated Transport COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Response To Extracellular Stimulus Protein-lipid Complex Assembly Protein Transport Establishment Of Protein Localization Plasma Lipoprotein Particle Remodeling Cholesterol Efflux Cellular Component Assembly Triglyceride Metabolic Process Protein Localization Vesicle Targeting, To, From Or Within Golgi Neutral Lipid Metabolic Process Response To Nutrient Levels Cholesterol Metabolic Process Plasma Lipoprotein Particle Clearance Sterol Metabolic Process Localization Within Membrane Vesicle Targeting Autophagic Vacuole Assembly Transport Cellular Lipid Catabolic Process Autophagy Regulation Of Catalytic Activity Response To Light Stimulus Macroautophagy Triglyceride Mobilization Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Membrane Organization Regulation Of Plasma Lipoprotein Particle Levels Low-density Lipoprotein Particle Remodeling Cholesterol Transport Sterol Transport Glycerolipid Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Signaling Phospholipid Efflux Negative Regulation Of Hydrolase Activity Endocytosis Regulation Of Protein Processing Regulation Of Proteolysis Phototransduction, Visible Light Cholesterol Homeostasis Cellular Response To Extracellular Stimulus Sterol Homeostasis	Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Adrenergic Receptor Signaling Pathway Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Regulation Of Protein Phosphorylation Negative Regulation Of CAMP-mediated Signaling Plasma Membrane To Endosome Transport Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorylation COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Golgi Vesicle Budding Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorus Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Vesicle Targeting, To, From Or Within Golgi Endosome Organization Regulation Of Cardiac Muscle Hypertrophy 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Vasodilation 7-methylguanosine RNA Capping Regulation Of Cellular Protein Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To ER Quinone Metabolic Process Drug Metabolic Process Transcription-coupled Nucleotide-excision Repair Localization Within Membrane Vesicle Targeting
Tagcloud ?		accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic	5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes searched sought srp19 surrounding taqman transformed variation volunteers yielded
Tagcloud (Difference) ?		accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic	5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes searched sought srp19 surrounding taqman transformed variation volunteers yielded
Tagcloud (Intersection) ?