ARFGAP1 and ASB10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ARFGAP1	ASB10
Description		ARF GTPase activating protein 1	ankyrin repeat and SOCS box containing 10
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction	Protein Ubiquitination Intracellular Signal Transduction
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Eyebrow thickness ( 26926045) Renal underexcretion gout ( 32238385)
Interacting Genes		39 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23	7 interacting genes: AGR3 ANTXR1 ARFGAP1 KDM1A LCN2 MEOX2 MRPL23
Entrez ID		55738	136371
HPRD ID		06443	10666
Ensembl ID		ENSG00000101199	ENSG00000146926
Uniprot IDs		Q53F62 Q8N6T3	A0A090N8I2 Q8WXI3
PDB IDs		3DWD 3O47
Enriched GO Terms of Interacting Partners?		Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance	Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Enterobactin Binding Cellular Response To Ionizing Radiation Positive Regulation Of Endothelial Tube Morphogenesis Response To Toxic Substance Iron Ion Sequestering Activity Positive Regulation Of Cold-induced Thermogenesis Ribosomal Subunit Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Herbicide Regulation Of Hippocampal Neuron Apoptotic Process Siderophore Transport Cytoplasmic Vesicle Lumen Response To Mycotoxin Regulation Of Cold-induced Thermogenesis Cellular Response To Radiation Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Response To Ionizing Radiation Somite Specification MRF Binding Protein Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Iron Ion Transport Response To Blue Light Response To Fungicide Guanine Metabolic Process Regulation Of Endothelial Cell Migration Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Histone H3K4 Demethylase Activity Cellular Response To X-ray Response To Fructose Histone H3K9 Demethylase Activity Negative Regulation Of Extracellular Matrix Assembly Dystroglycan Binding
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