PPP2R1A and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PPP2R1A	MAPK6
Description		protein phosphatase 2 scaffold subunit Aalpha	mitogen-activated protein kinase 6
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Cell Projection Neuron Projection Neuronal Cell Body Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex Glutamatergic Synapse INTAC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Chromosome Segregation Female Meiotic Nuclear Division Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Spindle Assembly Meiotic Spindle Elongation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Assembly RNA Polymerase II Transcription Initiation Surveillance Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	MAPK6/MAPK4 signaling
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS			Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		59 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 ATM CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 OGT PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC25A21-AS1 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		5518	5597
HPRD ID		16184	04213
Ensembl ID		ENSG00000105568	ENSG00000069956
Uniprot IDs		A8K7B7 B3KQV6 P30153	Q16659
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB	6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Intracellular Signal Transduction Intracellular Signaling Cassette Cytosol Protein Phosphatase 2A Binding Cytoplasm Protein Phosphatase Regulator Activity Signal Transduction Peroxiredoxin Activity Cellular Response To Oxygen-containing Compound Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Glutamatergic Synapse Response To Oxidative Stress G Protein Activity Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Cellular Response To Nerve Growth Factor Stimulus Tau Protein Binding Response To Nerve Growth Factor Removal Of Superoxide Radicals Response To Reactive Oxygen Species Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signaling Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding GTP Binding Protein Phosphatase Activator Activity Phosphatase Binding Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Regulation Of Protein Catabolic Process Cellular Response To Growth Factor Stimulus Peptidyl-threonine Phosphorylation Calmodulin Binding Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Localization	Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding
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