MAPK6 and ARHGDIA

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	ARHGDIA
Description		mitogen-activated protein kinase 6	Rho GDP dissociation inhibitor alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Immunological Synapse Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Rho Protein Signal Transduction Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Semaphorin-plexin Signaling Pathway Regulation Of Synaptic Vesicle Cycle
Pathways		MAPK6/MAPK4 signaling	Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B CEBPA EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		5597	396
HPRD ID		04213	03565
Ensembl ID		ENSG00000069956	ENSG00000141522
Uniprot IDs		Q16659	J3QQX2 P52565 V9HWE8
PDB IDs		6YKY 6YLC 6YLL 7AQB	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80 8X8T
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Negative Regulation Of Cellular Component Organization Cellular Response To Stress Erythrocyte Enucleation Regulation Of Primary Metabolic Process Actin Filament Organization Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Shelterin Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cytoskeleton Organization Post-translational Protein Modification Response To Stress Positive Regulation Of Metabolic Process Protein Modification Process Macromolecule Catabolic Process Positive Regulation Of Lamellipodium Assembly Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Developmental Process Negative Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Nuclear Telomere Cap Complex Positive Regulation Of Developmental Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Lamellipodium Assembly Fibroblast Apoptotic Process Positive Regulation Of Cell Adhesion Regulation Of Macromolecule Biosynthetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Telomere Capping Regulation Of Metabolic Process Small GTPase-mediated Signal Transduction Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Signaling Cassette
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