PPP2R1A and RAP1A

Number of citations of the paper that reports this interaction (PubMedID 17540176)
58

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PPP2R1A	RAP1A
Description		protein phosphatase 2 scaffold subunit Aalpha	RAP1A, member of RAS oncogene family
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Cell Projection Neuron Projection Neuronal Cell Body Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex Glutamatergic Synapse INTAC Complex	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Sperm Midpiece Presynapse Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Nucleotide Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Chromosome Segregation Female Meiotic Nuclear Division Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Spindle Assembly Meiotic Spindle Elongation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Assembly RNA Polymerase II Transcription Initiation Surveillance Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of D-glucose Import Positive Regulation Of Phagocytosis Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874 32581322) High altitude adaptation ( 28373541) Lymphocyte count ( 32888494) Osteoporosis-related phenotypes ( 20548944)
Interacting Genes		59 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 ATM CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 OGT PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC25A21-AS1 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C
Entrez ID		5518	5906
HPRD ID		16184	01545
Ensembl ID		ENSG00000105568	ENSG00000116473
Uniprot IDs		A8K7B7 B3KQV6 P30153	A8KAH9 P62834
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB	1C1Y 1GUA 3KUC 4KVG
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Intracellular Signal Transduction Intracellular Signaling Cassette Cytosol Protein Phosphatase 2A Binding Cytoplasm Protein Phosphatase Regulator Activity Signal Transduction Peroxiredoxin Activity Cellular Response To Oxygen-containing Compound Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Glutamatergic Synapse Response To Oxidative Stress G Protein Activity Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Cellular Response To Nerve Growth Factor Stimulus Tau Protein Binding Response To Nerve Growth Factor Removal Of Superoxide Radicals Response To Reactive Oxygen Species Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signaling Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding GTP Binding Protein Phosphatase Activator Activity Phosphatase Binding Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Regulation Of Protein Catabolic Process Cellular Response To Growth Factor Stimulus Peptidyl-threonine Phosphorylation Calmodulin Binding Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Localization	GTPase Regulator Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Guanyl-nucleotide Exchange Factor Activity Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of GTPase Activity Plasma Membrane Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of GTPase Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Hydrolase Activity Neurotrophin Signaling Pathway Epithelial Cell Development Rap Protein Signal Transduction Regulation Of Microvillus Assembly GTPase Binding Regulation Of Signal Transduction Regulation Of Apoptotic Process Cytosol Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Nerve Growth Factor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Death-inducing Signaling Complex Assembly Diacylglycerol Binding Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling CAMP Binding Fas Signaling Pathway Protein-containing Complex Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Regulation Of Developmental Process Protein-containing Complex Assembly GTPase Activator Activity Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Nucleosome Array Spacer Activity Positive Regulation Of Microvillus Assembly Regulation Of Cell Differentiation
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