MAPK6 and MAPKAPK5

Number of citations of the paper that reports this interaction (PubMedID 18720373)
0

Data Source:
HPRD (in vivo)

		MAPK6	MAPKAPK5
Description		mitogen-activated protein kinase 6	MAPK activated protein kinase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Dendritic Spine Development Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction
Pathways		MAPK6/MAPK4 signaling	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation
Drugs		Acetylsalicylic acid Minocycline Colforsin	Fostamatinib
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	32 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SNCA SRPK1 SRPK2 TAB1 TP53 YAP1 ZNF282 ZNF576
Entrez ID		5597	8550
HPRD ID		04213	09467
Ensembl ID		ENSG00000069956	ENSG00000089022
Uniprot IDs		Q16659	Q8IW41
PDB IDs		6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Cellular Response To Anisomycin Cytosol Kinase Activity Positive Regulation Of Cytokine Production Response To Anisomycin Nucleus Stress-activated MAPK Cascade Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Response To Stress Cellular Response To Stress Phosphorylation Cytoplasm Animal Organ Development Regulation Of Gene Expression Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Protein Localization To Tricellular Tight Junction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process ATP Binding Positive Regulation Of Biosynthetic Process Cellular Senescence Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia P38MAPK Cascade Cellular Response To Radiation Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Postsynapse Cellular Response To Oxygen-containing Compound Cellular Response To UV RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Transferase Activity Nucleotide Binding Cellular Response To Oxidative Stress Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress
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