MAPK6 and MOK

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		MAPK6	MOK
Name		mitogen-activated protein kinase 6	MOK protein kinase
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus Cytoplasm Cilium Cell Projection Ciliary Base
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Regulation Of Cell Cycle
Pathways		MAPK6/MAPK4 signaling	None
Drugs		Acetylsalicylic acid Minocycline Colforsin	None
GWAS		Frailty index ( 34431594 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )	Caudate nucleus volume ( 31530798 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Red cell distribution width ( 32888494 )
Novel Interactors		1 novel interactors: TCF12	None recorded
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	5 interacting genes: AKT1 CCNB1 JUN MAPK6 MYC
Entrez ID		5597	5891
HPRD ID		04213	09310
Ensembl ID		ENSG00000069956	ENSG00000080823
Uniprot IDs		Q16659	Q9UQ07
PDB IDs		6YKY 6YLC 6YLL 7AQB	Not available
GO Terms Enriched among Interactors		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Positive Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Metal Ion Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Ubiquitin-like Protein Ligase Binding MAPK Cascade Intracellular Signaling Cassette Positive Regulation Of Cell Population Proliferation Lymphocyte Apoptotic Process Integrated Stress Response Signaling Response To Xenobiotic Stimulus Response To Oxygen Levels Response To Metal Ion Response To Decreased Oxygen Levels Positive Regulation Of Organ Growth Leukocyte Apoptotic Process Regulation Of Cell Cycle Regulation Of Epithelial Cell Proliferation Positive Regulation Of MiRNA Transcription Euchromatin Positive Regulation Of MiRNA Metabolic Process Striated Muscle Cell Differentiation Protein Kinase Binding Positive Regulation Of Developmental Process Positive Regulation Of DNA-templated Transcription Initiation Cellular Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of Organ Growth Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of TRNA Methylation Response To DDT Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of MiRNA Metabolic Process Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stress Regulation Of Cell Population Proliferation Muscle Cell Differentiation Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction