MAPK6 and MIPEP

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	MIPEP
Description		mitogen-activated protein kinase 6	mitochondrial intermediate peptidase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Proteolysis Peptide Metabolic Process Protein Processing Involved In Protein Targeting To Mitochondrion
Pathways		MAPK6/MAPK4 signaling
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Femur bone mineral density x serum urate levels interaction ( 34046847) Fourth ventricle volume ( 31530798) Lung cancer ( 21725308) Myopia (pathological) ( 21640322) Venous thromboembolism ( 32232851) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	2 interacting genes: ILK MAPK6
Entrez ID		5597	4285
HPRD ID		04213	03761
Ensembl ID		ENSG00000069956	ENSG00000027001
Uniprot IDs		Q16659	Q99797
PDB IDs		6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Protein Kinase Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway ATP Binding Positive Regulation Of Developmental Process Protein Localization To Cell Cortex Septin Cytoskeleton Nucleotide Binding Tube Morphogenesis Hyaloid Vascular Plexus Regression Vascular Endothelial Growth Factor Receptor Activity Protein Phosphorylation Actin Cytoskeleton Phosphorylation Focal Adhesion Plasma Membrane Raft Assembly Protein Serine/threonine Kinase Activity Caveola Assembly Negative Regulation Of Vascular Endothelial Cell Proliferation Protein Kinase Binding Anatomical Structure Regression Membrane Raft Assembly Plasma Membrane Raft Organization Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Developmental Process Schwann Cell Development Fibroblast Migration Myelination In Peripheral Nervous System MAP Kinase Activity Kinase Activity Monocyte Chemotaxis Negative Regulation Of Neural Precursor Cell Proliferation Membrane Raft Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAP Kinase Activity Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Cell Proliferation Growth Factor Binding Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Migration Peptidyl-tyrosine Phosphorylation Branching Involved In Ureteric Bud Morphogenesis Nerve Development Intracellular Signaling Cassette Establishment Or Maintenance Of Apical/basal Cell Polarity Platelet Aggregation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
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