PPP2R1A and PTPA

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (two hybrid, biochemical, affinity chromatography technology)

		PPP2R1A	PTPA
Description		protein phosphatase 2 scaffold subunit Aalpha	protein phosphatase 2 phosphatase activator
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Cell Projection Neuron Projection Neuronal Cell Body Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex Glutamatergic Synapse INTAC Complex	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Chromosome Segregation Female Meiotic Nuclear Division Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Spindle Assembly Meiotic Spindle Elongation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Assembly RNA Polymerase II Transcription Initiation Surveillance Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Interacting Genes		59 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 ATM CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 OGT PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC25A21-AS1 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT
Entrez ID		5518	5524
HPRD ID		16184	02858
Ensembl ID		ENSG00000105568	ENSG00000119383
Uniprot IDs		A8K7B7 B3KQV6 P30153	F6WIT2 Q15257
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB	2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Intracellular Signal Transduction Intracellular Signaling Cassette Cytosol Protein Phosphatase 2A Binding Cytoplasm Protein Phosphatase Regulator Activity Signal Transduction Peroxiredoxin Activity Cellular Response To Oxygen-containing Compound Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Glutamatergic Synapse Response To Oxidative Stress G Protein Activity Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Cellular Response To Nerve Growth Factor Stimulus Tau Protein Binding Response To Nerve Growth Factor Removal Of Superoxide Radicals Response To Reactive Oxygen Species Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signaling Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding GTP Binding Protein Phosphatase Activator Activity Phosphatase Binding Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Regulation Of Protein Catabolic Process Cellular Response To Growth Factor Stimulus Peptidyl-threonine Phosphorylation Calmodulin Binding Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Localization	Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor
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