PPP2R1A and SLC6A2

Number of citations of the paper that reports this interaction (PubMedID 15963952)
0

Data Source:
HPRD (in vivo)

		PPP2R1A	SLC6A2
Description		protein phosphatase 2 scaffold subunit Aalpha	solute carrier family 6 member 2
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Cell Projection Neuron Projection Neuronal Cell Body Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex Glutamatergic Synapse INTAC Complex	Plasma Membrane Cell Surface Membrane Axon Synaptic Vesicle Membrane Neuronal Cell Body Membrane Presynaptic Membrane Cell Projection Neuron Projection Synapse
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Actin Binding Neurotransmitter Transmembrane Transporter Activity Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Symporter Activity Sodium:chloride Symporter Activity Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Chromosome Segregation Female Meiotic Nuclear Division Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Spindle Assembly Meiotic Spindle Elongation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Assembly RNA Polymerase II Transcription Initiation Surveillance Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Response To Xenobiotic Stimulus Monoamine Transport Norepinephrine Transport Sodium Ion Transmembrane Transport Response To Pain Dopamine Uptake Involved In Synaptic Transmission Norepinephrine Uptake Neuron Cellular Homeostasis Catecholamine Uptake Neurotransmitter Reuptake Chloride Transmembrane Transport
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	SLC-mediated transport of neurotransmitters Defective SLC6A2 causes orthostatic intolerance (OI)
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Amphetamine Phentermine Tramadol Guanadrel Reboxetine Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Methylphenidate Meperidine Imipramine Duloxetine Dextromethorphan Nortriptyline Amoxapine Mazindol Paroxetine Trimipramine Phenmetrazine Pseudoephedrine Cocaine Cyclobenzaprine Maprotiline Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Bupropion Guanethidine Orphenadrine Escitalopram Ketamine Clomipramine Ephedra sinica root Ephedrine Ginkgo biloba MMDA Midomafetamine Dextroamphetamine Metamfetamine Phendimetrazine Nomifensine Amineptine Debrisoquine Bicifadine Milnacipran XEN-2174 DDP-225 CRx-119 Amitifadine Mianserin Tesofensine Tapentadol Trodusquemine Desvenlafaxine Dexmethylphenidate Levomilnacipran Vortioxetine Dosulepin Viloxazine Zotepine Dasotraline Netarsudil Solriamfetol Serdexmethylphenidate
Diseases			Orthostatic intolerance (OI); Postural tachycardia syndrome (POTS)
GWAS			Birth weight ( 31043758) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		59 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 ATM CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 OGT PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC25A21-AS1 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	2 interacting genes: PPP2R1A STX1A
Entrez ID		5518	6530
HPRD ID		16184	01232
Ensembl ID		ENSG00000105568	ENSG00000103546
Uniprot IDs		A8K7B7 B3KQV6 P30153	H3BRE9 P23975
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB	8HFE 8HFF 8HFG 8HFI 8HFL 8I3V 8WGR 8WGX 8WTU 8WTV 8WTW 8WTX 8WTY 8XB2 8XB3 8XB4 8Y8Z 8Y90 8Y91 8Y92 8Y93 8Y94 8Y95 8YR2 8Z1L 8ZOY 8ZP1 8ZP2 8ZPB
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Intracellular Signal Transduction Intracellular Signaling Cassette Cytosol Protein Phosphatase 2A Binding Cytoplasm Protein Phosphatase Regulator Activity Signal Transduction Peroxiredoxin Activity Cellular Response To Oxygen-containing Compound Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Glutamatergic Synapse Response To Oxidative Stress G Protein Activity Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Cellular Response To Nerve Growth Factor Stimulus Tau Protein Binding Response To Nerve Growth Factor Removal Of Superoxide Radicals Response To Reactive Oxygen Species Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signaling Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding GTP Binding Protein Phosphatase Activator Activity Phosphatase Binding Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Regulation Of Protein Catabolic Process Cellular Response To Growth Factor Stimulus Peptidyl-threonine Phosphorylation Calmodulin Binding Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Localization	Meiotic Spindle Elongation Myosin Head/neck Binding Thromboxane A2 Receptor Binding Chromosome Separation Mitotic Sister Chromatid Separation Meiotic Sister Chromatid Cohesion Spindle Elongation Neuron Projection Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Meiotic Sister Chromatid Cohesion, Centromeric Protein Antigen Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Actomyosin Synaptic Vesicle Docking Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion ATP-dependent Protein Binding Regulation Of Synaptic Vesicle Priming Response To Gravity SNARE Complex Assembly Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Chloride Channel Inhibitor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Retinal Rod Cell Development Neural Tube Patterning Pericardium Development Nose Development Lateral Ventricle Development Calcium Channel Inhibitor Activity INTAC Complex FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Cellular Component Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Organelle Organization Glutamatergic Synapse Female Meiotic Nuclear Division Corpus Callosum Development Positive Regulation Of Neurotransmitter Secretion RNA Polymerase II Transcription Initiation Surveillance Establishment Of Planar Polarity Negative Regulation Of Hippo Signaling Myosin Binding Head Development Olfactory Bulb Development Presynaptic Active Zone Membrane Telencephalon Development Embryonic Hindlimb Morphogenesis
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