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PPP2R1A and CARD11
Number of citations of the paper that reports this interaction (PubMedID
21157432
)
53
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
PPP2R1A
CARD11
Description
protein phosphatase 2 scaffold subunit Aalpha
caspase recruitment domain family member 11
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Dendrite
Cell Projection
Neuron Projection
Neuronal Cell Body
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
Glutamatergic Synapse
INTAC Complex
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Membrane
CBM Complex
Membrane Raft
Extracellular Exosome
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Heterodimerization Activity
Protein Antigen Binding
GMP Kinase Activity
Protein Binding
CARD Domain Binding
Biological Process
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Chromosome Segregation
Female Meiotic Nuclear Division
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Spindle Assembly
Meiotic Spindle Elongation
Mitotic Sister Chromatid Separation
Meiotic Sister Chromatid Cohesion, Centromeric
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein-containing Complex Assembly
RNA Polymerase II Transcription Initiation Surveillance
Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Immune System Process
Signal Transduction
Canonical NF-kappaB Signal Transduction
B Cell Differentiation
Positive Regulation Of B Cell Proliferation
T Cell Costimulation
Positive Regulation Of Interleukin-2 Production
CD4-positive, Alpha-beta T Cell Proliferation
TORC1 Signaling
B Cell Proliferation
T Cell Activation
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Thymic T Cell Selection
Regulation Of B Cell Differentiation
Regulation Of T Cell Differentiation
GMP Metabolic Process
Lymphocyte Activation
GDP Metabolic Process
Homeostasis Of Number Of Cells
Regulation Of Immune Response
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Homooligomerization
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Initiation of Nuclear Envelope (NE) Reformation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Asthma (
34103634
)
Atopic dermatitis (
23042114
)
Cadmium levels (
26025379
)
Daytime sleep phenotypes (
27126917
)
Dupuytren's disease (
28886342
)
Intracranial aneurysm (
29531279
)
Multiple sclerosis (
24076602
31604244
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (
34099189
)
Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) (
34099189
)
Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction (
34099189
)
Ulcerative colitis (
23128233
)
White matter integrity (
23218918
)
Interacting Genes
59 interacting genes:
AIMP2
AKT1
AMOTL2
ARIH2
ATM
CARD11
CARHSP1
CDC42
CDK1
CSDC2
CSNK2B
DAPK1
DELEC1
DUX4
EEF2
ESR1
FBXO43
GNA12
GOLGA6A
GOLGA8F
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
LINC01554
MAP3K7
MAPK6
MCM3
OGT
PARK7
PLAAT3
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP2R5B
PPP4C
PPP5C
PRDX1
PRDX2
PTPA
RAB11A
RAB18
RAB7A
RAP1A
RORC
SGO1
SGO2
SLC25A21-AS1
SLC6A2
SMAD2
SMAD3
STRN
STRN3
SUMO2
TAB1
TRADD
ZFYVE9
15 interacting genes:
BCL10
IKBKG
MAP3K7
MAP4K1
PDPK1
PPP2CA
PPP2R1A
PRKCB
PRKCQ
RNF181
SH2D3C
SRPK2
TAB1
WDR1
ZAP70
Entrez ID
5518
84433
HPRD ID
16184
06234
Ensembl ID
ENSG00000105568
ENSG00000198286
Uniprot IDs
A8K7B7
B3KQV6
P30153
Q9BXL7
PDB IDs
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
4LAC
5W0W
6IUR
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
4JUP
4LWD
Enriched GO Terms of Interacting Partners
?
Protein Phosphatase Type 2A Complex
Intracellular Signal Transduction
Intracellular Signaling Cassette
Cytosol
Protein Phosphatase 2A Binding
Cytoplasm
Protein Phosphatase Regulator Activity
Signal Transduction
Peroxiredoxin Activity
Cellular Response To Oxygen-containing Compound
Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Glutamatergic Synapse
Response To Oxidative Stress
G Protein Activity
Positive Regulation Of Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein-containing Complex
Regulation Of Cell Communication
Regulation Of Signaling
Response To Growth Factor
Cellular Response To Nerve Growth Factor Stimulus
Tau Protein Binding
Response To Nerve Growth Factor
Removal Of Superoxide Radicals
Response To Reactive Oxygen Species
Positive Regulation Of Cell Communication
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signaling
Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Cell Population Proliferation
Regulation Of Programmed Cell Death
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Protein-containing Complex Binding
GTP Binding
Protein Phosphatase Activator Activity
Phosphatase Binding
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
FAR/SIN/STRIPAK Complex
Regulation Of Protein Catabolic Process
Cellular Response To Growth Factor Stimulus
Peptidyl-threonine Phosphorylation
Calmodulin Binding
Protein Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Localization
Intracellular Signal Transduction
Immune System Process
Intracellular Signaling Cassette
Immune Response-regulating Signaling Pathway
Protein Kinase Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Protein Serine Kinase Activity
Protein Phosphorylation
Immune Response-activating Signaling Pathway
Regulation Of Immune Response
Kinase Activity
Phosphorylation
Positive Regulation Of Immune System Process
Protein Serine/threonine Kinase Activity
Positive Regulation Of Immune Response
Regulation Of Intracellular Signal Transduction
Signal Transduction
Activation Of Immune Response
Positive Regulation Of Signal Transduction
Cytoplasm
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Linear Polyubiquitin Binding
Non-canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Canonical NF-kappaB Signal Transduction
Immunological Synapse
MAP Kinase Kinase Kinase Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Canonical NF-kappaB Signal Transduction
Regulation Of Immune System Process
JNK Cascade
Positive Regulation Of CGAS/STING Signaling Pathway
Lymphocyte Homeostasis
Protein Modification Process
Transferase Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Leukocyte Homeostasis
Positive Regulation Of NF-kappaB Transcription Factor Activity
Anoikis
Protein Serine/threonine Phosphatase Activity
Kinase Activator Activity
Positive Regulation Of T Cell Activation
Phosphate-containing Compound Metabolic Process
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