MAPK6 and ZNF133

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	ZNF133
Description		mitogen-activated protein kinase 6	zinc finger protein 133
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		MAPK6/MAPK4 signaling	Generic Transcription Pathway
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Body mass index ( 28892062 29273807) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	9 interacting genes: APP FOS ILK KRTAP10-7 MAPK6 MDM2 PDPK1 TIAM1 TRIM28
Entrez ID		5597	7692
HPRD ID		04213	04964
Ensembl ID		ENSG00000069956	ENSG00000125846
Uniprot IDs		Q16659	P52736
PDB IDs		6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Positive Regulation Of Developmental Process Intracellular Signaling Cassette Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Positive Regulation Of Protein Localization SUMO Transferase Activity Response To Immobilization Stress Cellular Response To Peptide Hormone Stimulus Protein Kinase Activity Amyloid Fibril Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Transport Cellular Response To Epidermal Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Response To Metal Ion Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Regulation Of Cell Differentiation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein-containing Complex Positive Regulation Of Transport Glial Cell Development Response To Peptide Hormone Response To Epidermal Growth Factor Medium-term Memory Cellular Response To Prolactin Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Nucleocytoplasmic Transport Protein Sumoylation 3-phosphoinositide-dependent Protein Kinase Activity Cytosol Cellular Response To Hormone Stimulus Promoter-specific Chromatin Binding Cellular Response To Oxygen-containing Compound Regulation Of MiRNA Transcription Regulation Of Receptor Internalization Regulation Of Cell Population Proliferation Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity
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